Noam Ziv, PhD
Professor of Physiology
PhD, 1994 - Hebrew University, Israel
Synaptic maintenance, remodeling and tenacity
At a fundamental level, the central nervous system (CNS) may be viewed as a vast network of nerve cells interconnected by synapses, cell-to-cell contacts specialized for signal transmission. Synapses are widely believed to constitute loci at which modifications, driven by particular activation histories, bring about persistent changes in functional properties of neuronal networks. CNS synapses, however, are minute, often located at enormous distances from the cells’ biosynthetic centers, and are composed of remarkably dynamic proteins. It is thus unclear if, and to what extent, synapses can maintain their individual properties over behavioral time scales. We have been using proteomics, advanced imaging techniques and multielectrode array recordings to study the dynamics and turnover of synaptic molecules, the capacity of synapses to preserve their individual properties, the degree to which this capacity depends on activity and the rules and principles that govern directed and spontaneous remodeling of excitatory and inhibitory synaptic specializations.
Kaufman M, Reinartz S, and Ziv NE. 2014. Adaptation to prolonged neuromodulation in cortical cultures: an invariable return to network synchrony. BMC Biol. 12, 83.
Statman A, Kaufman M, Minerbi A, Ziv NE, and Brenner N. 2014. Synaptic size dynamics as an effectively stochastic process. PLoS Comput Biol. 10(10), e1003846.
Ziv NE and Fisher-Lavie A. 2014. Presynaptic and postsynaptic scaffolds: dynamics fast and slow. Neuroscientist 20, 439-452.
Fisher-Lavie A and Ziv NE. 2013. Matching dynamics of presynaptic and postsynaptic scaffolds. J. Neurosci. 33, 13094-13100.
Cohen LD, Zuchman R, Sorokina O, Müller A, Dieterich DC, Armstrong JD, Ziv T, and Ziv NE. 2013. Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance. PLoS One 8(5), e63191.
A cortical neuron, expressing a GFP-tagged variant of the synaptic protein PSD95, growing on a multielectrode array.
Fluorescent spots represent excitatory synapses formed on this neuron. Locations of four electrodes are shown as yellow circles.