About Us Research Groups Publications Rappaport Prize Conferences News Links Contact Us  

Noam Ziv, PhD

Professor of Physiology

PhD, 1994 - Hebrew University, Israel

Synaptic maintenance, remodeling and tenacity


At a fundamental level, the central nervous system (CNS) may be viewed as a vast network of nerve cells interconnected by synapses, cell-to-cell contacts specialized for signal transmission. Synapses are widely believed to constitute loci at which modifications, driven by particular activation histories, bring about persistent changes in functional properties of neuronal networks. CNS synapses, however, are minute, often located at enormous distances from the cells’ biosynthetic centers, and are composed of remarkably dynamic proteins. It is thus unclear if, and to what extent, synapses can maintain their individual properties over behavioral time scales.  We have been using proteomics, advanced imaging techniques and multielectrode array recordings to study the dynamics and turnover of synaptic molecules, the capacity of synapses to preserve their individual properties, the degree to which this capacity depends on activity and the rules and principles that govern directed and spontaneous remodeling of excitatory and inhibitory synaptic specializations.

 

Representative publications


Kaufman M, Reinartz S, and Ziv NE. 2014. Adaptation to prolonged neuromodulation in cortical cultures: an invariable return to network synchrony. BMC Biol. 12, 83.


Statman A, Kaufman M, Minerbi A, Ziv NE, and Brenner N. 2014. Synaptic size dynamics as an effectively stochastic process.  PLoS Comput Biol. 10(10), e1003846.

 

Ziv NE and Fisher-Lavie A. 2014. Presynaptic and postsynaptic scaffolds: dynamics fast and slow. Neuroscientist 20, 439-452.

 

Fisher-Lavie A and Ziv NE. 2013. Matching dynamics of presynaptic and postsynaptic scaffolds. J. Neurosci. 33, 13094-13100.

 

Cohen LD, Zuchman R, Sorokina O, Müller A, Dieterich DC, Armstrong JD, Ziv T, and Ziv NE. 2013. Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance. PLoS One 8(5), e63191.

 

Figure legend:

A cortical neuron, expressing a GFP-tagged variant of the synaptic protein PSD95, growing on a multielectrode array.

Fluorescent spots represent excitatory synapses formed on this neuron. Locations of four electrodes are shown as yellow circles.

 

 

 

Email: noamz@technion.ac.il
A cortical neuron, expressing a GFP-tagged variant of the synaptic protein PSD95, growing on a multielectrode array.
A cortical neuron, expressing a GFP-tagged variant of the synaptic protein PSD95, growing on a multielectrode array.
Show Publications
By Year
By Author
Publication Search
Keyword (s)
Topic
Date
 
Related Links

BioRap Technologies Ltd.

Technion

Faculty of Medicine

Important Events

The Nobel Prize in Chemistry 2004

Professors Avram Hershko and Aaron Ciechanover - winners of the 2004 Nobel Prize in Chemistry.
  1 Efron Street, P.O. Box 9697, Haifa 31096, Israel,
Tel: 972-4-829-5365, Fax: 972-4-855-2296, Email: edelman@tx.technion.ac.il
2006 Rappaport Institute. All Rights Reserved. Created by Catom web design