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Adi Salzberg, DSc

Associate Professor of Genetics

DSc, 1992 - Technion, Israel

Cell fate diversification in the Drosophila chordotonal organ lineage

One of the fascinating questions in developmental biology is how different cells, which develop within a given organ, acquire different properties that allow them to work together as a functional unit. We are using the proprioceptive organs in the peripheral nervous system (PNS) of Drosophila (also called chordotonal organs, ChOs) as a model system for studying cell fate diversification. The fly ChOs consist of five lineage-related cell types with distinct identities and properties. Very little is known about the mechanisms regulating the specification of the various ChO cell identities. We have constructed a unique transgenic fly strain in which different ChO cell types are labeled with different fluorescent reporters. This strain is used as the basis for large-scale RNAi-based F1 screens for novel determinants of cell fate specification in the ChO lineage. In addition this strain allows us, for the first time, to study post-embryonic development and morphogenesis of ChOs.


Representative publications

Nachman A, Halachmi N, Matia N, Manzur D, and Salzberg A. 2015. Deconstructing the complexity of regulating common properties in different cell types: lessons from the delilah gene. Dev Biol. 403, 180-191.


Zohar-Stoopel A*, Drucker-Gonen N*, Mahroum M, Ben-Zvi DS, Toledano H and Salzberg A 2014. Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules. Dev Dyn. 243, 132-144. * These authors contributed equally to the work.


Pechkovsky A, Lahav M, Bitman E, Salzberg A *, and Kleinberger T.* 2013. E4orf4 induces PP2A- and Src-dependent cell-death in Drosophila melanogaster and at the same time inhibits classical apoptosis pathways. Proc Natl Acad Sci USA 110, E1724-33. *Co-corresponding authors.


Halachmi N, Nachman A, and Salzberg A. 2012. Visualization of proprioceptors in Drosophila larvae and pupae. J. Vis. Exp. 64, e3846.


Egoz-Matia N, Nachman A, Halachmi N, Toder M, Klein Y, and Salzberg A. 2011. Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. Dev Biol. 351, 99-109.


Figure legend:


Visualizing the chordotonal organs of a fly embryo.

A lateral view of four abdominal segments of a fly embryo carrying a chordotonal-specific reporter (deiChO-lacZ stained in red), stained for the chordotonal specific α-tubulin 85E (blue) and for the neuronal marker ELAV (green). Eight chordotonal organs are present in each segment: the ventral VChA and VChB, the lateral LCh1 organ and five organs clustered in the LCh5 organ. The cap-attachment (CA), cap cells (C), neurons (N) and ligament cells (L) of the LCh5 organs are denoted.




Email: adis@tx.technion.ac.il
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The Nobel Prize in Chemistry 2004

Professors Avram Hershko and Aaron Ciechanover - winners of the 2004 Nobel Prize in Chemistry.
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