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Dori Derdikman, PhD

Assistant Professor of Neuroscience

PhD, 2006 - Weizmann Institute, Israel

Studying spatial perception and memory

 

How is space represented in the brain? How do we form our spatial memory? How are space and time related in the brain? What is the neuronal code for space? My lab researches these and related questions. We use diverse methods to conduct neuroscience research, including state-of-the-art electrophysiological recordings using tetrodes from awake-behaving animals, both tethered and telemetry-based, virtual-reality setups for animals, optogenetic methods, and mathematical modeling. The multi-disciplinary work in the lab encompasses collaborations between biologists, electrical engineers, medical researchers, physicists, computer scientists, and mathematicians, all under the umbrella of brain science. We record neurons in the brain's spatial cognitive map system, including grid cells in the entorhinal cortex, place cells in the hippocampus, and head-direction cells. We strive to understand the neural networks that encode our perception and dictate the animal's behavior in such spaces.
For more information, see: http://derdiklab.technion.ac.il/


Representative publications


Tocker G, Barak O, and Derdikman D. 2015. Grid cells correlation structure suggests organized feedforward projections from deep to superficial layers in the MEC. Hippocampus (in press)

 

Finkelstein A*, Derdikman D*, Rubin A, Foerster JN, Las L, and Ulanovsky N. 2015. Three-dimensional head-direction coding in the bat brain. Nature 517, 159-164. *Equal Contribution

 

Derdikman D and Knierim J.J. Eds. 2014. Space, Time and Memory in the Hippocampal Formation. Springer, Wien.

 

Derdikman D and Moser EI. 2010. A manifold of spatial maps in the brain. Trends in Cognitive Sciences 14, 561-569.

 

Derdikman D, Whitlock JR, Tsao A, Fyhn M, Hafting T, Moser M-B, and Moser EI. 2009.  Fragmentation of grid cell maps in a multicompartment environment. Nature Neuroscience 12, 1325-1332.

 

Figure legend:

Examples of grid cells from our research.

Two classes of grid cells are separable. Representative examples of a pure-grid cell (A-C) and a conjunctive cell (D-F) in the medial entorhinal cortex: (A, D) Spatial autocorrelation plots; (B, E) Head-direction histograms; (C, F) Theta-phase histograms. (G) Population of cell clusters according to Rayleigh vector of theta-phase locking (x-axis) and Rayleigh vector of head-directionality (y-axis).  Figure taken from Tocker et al., 2015

 

 

 

Email: derdik@technion.ac.il
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