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Developmental Biology and Cancer Research

 
Heparanase co-operates with Ras to drive breast and skin tumorigenesis
2014
Israel Vlodavsky, PhD
Authors : Boyango I, Barash U, Naroditsky I, Li JP, Hammond E, Ilan N, Vlodavsky I.
Cancer Res. 2014 Jun 26. pii: canres.2962.2013. [Epub ahead of print]
 
Anti-Bv8 Antibody and Metronomic Gemcitabine Improve Pancreatic Adenocarcinoma Treatment Outcome Following Weekly Gemcitabine Therapy
2014
Yuval Shaked, PhD
Authors : Hasnis E, Alishekevitz D, Gingis-Veltski S, Bril R, Fremder E, Voloshin T, Raviv Z, Karban A, Shaked Y.
Neoplasia. 2014 Jun 20. pii: S1476-5586(14)00065-7.
 
Expression of heparanase in soft tissue sarcomas of adults
2014
Israel Vlodavsky, PhD
Authors : Kazarin O, Ilan N, Naroditzky I, Ben-Itzhak O, Vlodavsky I, Bar-Sela G.
J Exp Clin Cancer Res. 2014 May 10;33(1):39.
 
Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin
2014
Israel Vlodavsky, PhD
Authors : Shteingauz A, Ilan N, Vlodavsky I.
Cell Mol Life Sci. 2014 May 1. [Epub ahead of print]
 
Anti-VEGF-A Affects the Angiogenic Properties of Tumor-Derived Microparticles
2014
Yuval Shaked, PhD
Authors : Munster M, Fremder E, Miller V, Ben-Tsedek N, Davidi S, Scherer SJ, Shaked Y.
PLoS One. 2014 Apr 21;9(4):e95983.
 
Heparanase expression in Langerhans cell histiocytosis
2014
Israel Vlodavsky, PhD
Authors : Dvir R, Vlodavsky I, Ilan N, Bitan M, Issacov J, Elhasid R.
Pediatr Blood Cancer. 2014 Apr 15. doi: 10.1002/pbc.25046. [Epub ahead of print]
 
Small But Mighty: Microparticles as Mediators of Tumor Progression
2014
Yuval Shaked, PhD
Authors : Voloshin T, Fremder E, Shaked Y.
Cancer Microenviron. 2014 Apr 6. [Epub ahead of print]
 
Lenalidomide and metronomic melphalan for CMML and higher risk MDS: A phase 2 clinical study with biomarkers of angiogenesis
2014
Yuval Shaked, PhD
Authors : Buckstein R, Kerbel R, Cheung M, Shaked Y, Chodirker L, Lee CR, Lenis M, Davidson C, Cussen MA, Reis M, Chesney A, Zhang L, Mamedov A, Wells RA.
Leuk Res. 2014 Apr 5. pii:S0145-2126(14)00097-6.
 
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
2014
Israel Vlodavsky, PhD
Authors : Hunter KE, Palermo C, Kester JC, Simpson K, Li JP, Tang LH, Klimstra DS, Vlodavsky I, Joyce JA.
Oncogene. 2014 Apr 3;33(14):1799-808.
 
NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and independent mechanisms and contribute to induction of cell death
2014
Tamar Kleinberger, PhD
Authors : Avital-Shacham M, Sharf R, Kleinberger T.
J Virol. 2014 Mar 26. [Epub ahead of print] PubMed PMID: 24672025
 
Treatment-induced host-mediated mechanisms reducing the efficacy of antitumor therapies
2014
Yuval Shaked, PhD
Authors : Daenen LG, Houthuijzen JM, Cirkel GA, Roodhart JM, Shaked Y, Voest EE.
Oncogene. 2014 Mar 13;33(11):1341-7.
 
The potential of heparanase as a therapeutic target in cancer
2014
Israel Vlodavsky, PhD
Authors : Pisano C, Vlodavsky I, Ilan N, Zunino F.
Biochem Pharmacol. 2014 May 1;89(1):12-9.
 
Heparanase interacts with resistin and augments its activity
2014
Israel Vlodavsky, PhD
Authors : Novick D, Barak S, Ilan N, Vlodavsky I.
PLoS One. 2014 Jan 21;9(1):e85944.
 
Parallel waves of inductive signaling and mesenchyme maturation regulate differentiation of the chick mesonephros
2014
Tom Schultheiss, MD, PhD
Authors : Soueid-Baumgarten S, Yelin R, Davila EK, Schultheiss TM.
Dev Biol. 2014 Jan 1;385(1):122-35.
 
Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase
2013
Israel Vlodavsky, PhD
Authors : Zhang D, Wan A, Chiu AP, Wang Y, Wang F, Neumaier K, Lal N, Bround MJ, Johnson JD, Vlodavsky I, Rodrigues B.
Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2830-8.
 
Low-dose metronomic chemotherapy: from past experience to new paradigms in the treatment of cancer
2013
Yuval Shaked, PhD
Authors : Loven D, Hasnis E, Bertolini F, Shaked Y.
Drug Discov Today. 2013 Feb;18(3-4):193-201.
 
Lysyl oxidase-like-2 promotes tumour angiogenesis and is a potential therapeutic target in angiogenic tumours
2013
Gera Neufeld, PhD
Authors : Zaffryar-Eilot S, Marshall D, Voloshin T, Bar-Zion A, Spangler R, Kessler O, Ghermazien H, Brekhman V, Suss-Toby E, Adam D, Shaked Y, Smith V, Neufeld G.
Carcinogenesis. 2013 Oct;34(10):2370-9.
 
Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP
2013
Israel Vlodavsky, PhD
Authors : Ostrovsky O, Shimoni A, Baryakh P, Morgulis Y, Mayorov M, Beider K, Shteingauz A, Ilan N, Vlodavsky I, Nagler A.
J Leukoc Biol. 2013 Dec 6. [Epub ahead of print] PubMed PMID: 24319286.
 
PTK7 modulates Wnt signaling activity via LRP6
2013
Dale Frank, PhD
Authors : Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D.
Development. 2014 Jan;141(2):410-21.
 
The Many Faces of Sensorineural Hearing Loss: One Founder and Two Novel Mutations Affecting One Family of Mixed Jewish Ancestry
2013
Tamar Ben-Yosef, PhD
Authors : Behar DM, Davidov B, Brownstein Z, Ben-Yosef T, Avraham KB, Shohat M.
Genet Test Mol Biomarkers. 2013 Dec 24. [Epub ahead of print] PubMed PMID: 24367894.
 
Tumor-derived microparticles induce bone marrow-derived cell mobilization and tumor homing: A process regulated by osteopontin
2013
Yuval Shaked, PhD
Authors : Fremder E, Munster M, Aharon A, Miller V, Gingis-Velitski S, Voloshin T, Alishekevitz D, Bril R, Scherer SJ, Loven D, Brenner B, Shaked Y.
Int J Cancer. 2014 Jul 15;135(2):270-81.
 
Generation of the podocyte and tubular components of an amniote kidney: timing of specification and a role for Wnt signaling
2013
Tom Schultheiss, MD, PhD
Authors : Grinstein M, Yelin R, Herzlinger D, Schultheiss TM.
Development. 2013 Nov;140(22):4565-73.
 
Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.
2013
Israel Vlodavsky, PhD
Authors : Lerner I, Zcharia E, Neuman T, Hermano E, Rubinstein AM, Vlodavsky I, Elkin M.
Cell Mol Life Sci. 2013 Oct 30. [Epub ahead of print] PubMed PMID: 24169805.
 
Differential therapeutic effects of anti-VEGF-A antibody in different tumor models: implications for choosing appropriate tumor models for drug testing.
2013
Yuval Shaked, PhD
Authors : Alishekevitz D, Bril R, Loven D, Miller V, Voloshin T, Gingis-Velitski S, Fremder E, Scherer SJ, Shaked Y.
Mol Cancer Ther. 2013 Oct 22. [Epub ahead of print] PubMed PMID: 24150126.
 
E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways
2013
Adi Salzberg, DSc
Authors : Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T.
Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1724-33.
 
Heparanase expression in periapical granulomas and radicular cysts
2013
Israel Vlodavsky, PhD
Authors : Elad S, Sherman Y, Palmon A, Vlodavsky I, Or R.
Odontology. 2013 Jan;101(1):96-102.
 
Live Imaging of Apoptotic Cell Clearance during Drosophila Embryogenesis
2013
Estee Kurant, PhD
Authors : Shklyar B, Shklover J, Kurant E.
J Vis Exp. 2013 Aug 18;(78). doi: 0.3791/50151.
 
Poly(ethylene glycol)-paclitaxel-alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases
2013
Yuval Shaked, PhD
Authors : Miller K, Clementi C, Polyak D, Eldar-Boock A, Benayoun L, Barshack I, Shaked Y, Pasut G, Satchi-Fainaro R.
Biomaterials. 2013 May;34(15):3795-806.
 
Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55 alpha subunit
2013
Tamar Kleinberger, PhD
Authors : Horowitz B, Sharf R, Avital-Shacham M, Pechkovsky A, Kleinberger T.
J Biol Chem. 2013 May 10;288(19):13718-27.
 
The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis
2013
Tamar Kleinberger, PhD  |   Adi Salzberg, DSc
Authors : Pechkovsky A, Salzberg A, Kleinberger T.
2013 Aug 1;12(15):2343-4.
 
Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development
2013
Eyal Bengal, PhD
Authors : Kolpakova A, Katz S, Keren A, Rojtblat A, Bengal E.
PLoS One. 2013 Jul 19;8(7):e69693.
 
Caspase activity is required for engulfment of apoptotic cells.
2013
Estee Kurant, PhD
Authors : Shklyar B, Levy-Adam F, Mishnaevski K, Kurant E.
Mol Cell Biol. 2013 Aug;33(16):3191-201.
 
Heparanase: multiple functions in inflammation, diabetes and atherosclerosis
2013
Israel Vlodavsky, PhD
Authors : Vlodavsky I, Iozzo RV, Sanderson RD.
Matrix Biol. 2013 Jun 24;32(5):220-2.
 
Involvement of heparanase in atherosclerosis and other vessel wall pathologies
2013
Israel Vlodavsky, PhD
Authors : Vlodavsky I, Blich M, Li JP, Sanderson RD, Ilan N.
Matrix Biol. 2013 Jun 24;32(5):241-51.
 
In vitro enrichment of tumor-initiating cells from human established cell lines.
2013
Yuval Shaked, PhD
Authors : Benayoun L, Shaked Y.
Curr Protoc Stem Cell Biol. 2013 Feb;Chapter 3:Unit 3.7. doi: 10.1002/9780470151808.sc0307s24. PubMed PMID: 23404675.
 
Caspase Activity is Required for Engulfment of Apoptotic Cells
2013
Estee Kurant, PhD
Authors : Authors: Shklyar B, Levy-Adam F, Mishnaevski K, Kurant E.
Mol Cell Biol. 2013 Jun 10. [Epub ahead of print]
 
E4orf4 induces PP2A- and Src-dependent cell-death in Drosophila melanogaster and at the same time inhibits classical apoptosis pathways
2013
Tamar Kleinberger, PhD  |   Adi Salzberg, DSc
Authors : Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T.
Proc. Natl. Acad. Sci. USA, 110, E1724-33.
 
Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules.
2013
Adi Salzberg, DSc
Authors : Zohar-Stoopel A, Gonen N, Mahroum M, Ben-Zvi DS, Toledano H, Salzberg A.
Developmental Dynamics, 2013, [Epub ahead of print]
 
Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression
2013
Israel Vlodavsky, PhD
Authors : Blich M, Golan A, Arvatz G, Sebbag A, Shafat I, Sabo E, Cohen-Kaplan V, Petcherski S, Avniel-Polak S, Eitan A, Hammerman H, Aronson D, Axelman E, Ilan N, Nussbaum G, Vlodavsky I.
Arterioscler. Thromb. Vasc. Biol. 33:e56-65.
 
Significance of Heparanase in Cancer and Inflammation.
2012
Israel Vlodavsky, PhD
Authors : Vlodavsky I, Beckhove P, Lerner I, Pisano C, Meirovitz A, Ilan N, Elkin M.
Cancer Microenviron. 5(2):115-32.
 
Identification of possible cigarette smoke constituents responsible for muscle catabolism
2012
Abraham Z. Reznick, PhD
Authors : Rom O, Kaisari S, Aizenbud D, Reznick AZ.
J Muscle Res Cell Motil. 2012 May 22. [Epub ahead of print]
 
A hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation
2012
Dale Frank, PhD
Authors : Elkouby YM, Polevoy H, Gutkovich YE, Michaelov A, Frank D.
Development. 139(8):1487-97.
 
The involvement of oxidants and NF-KB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells.
2012
Abraham Z. Reznick, PhD
Authors : Ben-David D, Livne E, Reznick AZ.
Inflamm Res. 2012 Mar 13. [Epub ahead of print]
 
The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans.
2012
Abraham Z. Reznick, PhD
Authors : Gochman E, Mahajna J, Shenzer P, Dahan A, Blatt A, Elyakim R, Reznick AZ.
Acta Histochem. 2012 Mar 12. [Epub ahead of print]
 
Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer
2012
Israel Vlodavsky, PhD
Authors : Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, Doweck I, Vlodavsky I.
J Biol Chem. 2012 Feb 24;287(9):6668-78.
 
Analysis of Nephric Duct Specification in the Avian Embryo
2012
Tom Schultheiss, MD, PhD
Authors : Attia L, Yelin R, Schultheiss TM.
Development 139, 4143-51.
 
Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice
2012
Israel Vlodavsky, PhD
Authors : Benhamron S, Reiner I, Zcharia E, Atallah M, Grau A, Vlodavsky I, Mevorach D.
PLoS One. 2012;7(5):e35602.
 
Heparanase induces STAT protein phosphorylation: pre-clinical and clinical significance in head and neck cancer
2012
Israel Vlodavsky, PhD
Authors : Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, Doweck I, Vlodavsky I.
J Biol Chem. 287, 6668-78.
 
Live imaging of apoptotic cell clearance during Drosophila embryogenesis
2012
Estee Kurant, PhD
Authors : Shklyar B, Shklover J, Kurant E.
JoVE. In press.
 
The Enzymatic Activity of Lysyl Oxidas-like-2 (LOXL2) Is Not Required for LOXL2-induced Inhibition of Keratinocyte Differentiation
2012
Gera Neufeld, PhD
Authors : Lugassy J., Zaffryar-Eilot S, Soueid S, Mordoviz A, Smith V, Kessler O, Neufeld G.
J. Biol. Chem. 287, 3541-3549
 
Tumor initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs
2012
Yuval Shaked, PhD
Authors : Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer SJ, Shaked Y.
Stem Cells 30, 1831-41.
 
Visualization of proprioceptors in Drosophila larvae and pupae
2012
Adi Salzberg, DSc
Authors : Halachmi N, Nachman A, Salzberg A.
J. Vis. Exp. 64, e3846, DOI: 10.3791/3846.
 
Heparanase Is Highly Expressed and Regulates Proliferation in GH-Secreting Pituitary Tumor Cells.
2011
Israel Vlodavsky, PhD
Authors : Rubinfeld H, Cohen-Kaplan V, Nass D, Ilan N, Meisel S, Cohen ZR, Hadani M,Vlodavsky I, Shimon I.
Endocrinology. 2011 Dec;152(12):4562-70.
 
Host Response to Short-term, Single-Agent Chemotherapy Induces Matrix Metalloproteinase-9 Expression and Accelerates Metastasis in Mice.
2011
Yuval Shaked, PhD
Authors : Gingis-Velitski S, Loven D, Benayoun L, Munster M, Bril R, Voloshin T,
Cancer Res. 2011 Nov 15;71(22):6986-96.
 
A panel of glycan cell surface markers define pluripotency state and promote safer cell-based therapies.
2011
Joseph Itskovitz-Eldor, MD, DSc
Authors : Itskovitz-Eldor J.
Cell Stem Cell. 2011 Oct 4;9(4):291-2.
 
A fly view of a SUMO-targeted ubiquitin ligase
2011
Amir Orian, MD, PhD
Authors : Abed M, Bitman-Lotan E, Orian A.
Fly (Austin). 2011 Oct-Dec;5(4):340-4.
 
Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure.
2011
Joseph Itskovitz-Eldor, MD, DSc
Authors : Gherghiceanu M, Barad L, Novak A, Reiter I, Itskovitz-Eldor J, Binah O, Popescu LM.
J Cell Mol Med. 2011 Aug 24. [Epub ahead of print]
 
The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.
2011
Tamar Kleinberger, PhD
Authors : Brestovitsky A, Sharf R, Mittelman K, Kleinberger T.
Nucleic Acids Res. 2011 Aug;39(15):6414-27.
 
FAK and WNT Signaling: The Meeting of Two Pathways in Cancer and Development.
2011
Dale Frank, PhD
Authors : Fonar Y, Frank D.
Anticancer Agents Med Chem. 11(7):600-6. Review.
 
G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist.
2011
Yuval Shaked, PhD
Authors : Voloshin T, Gingis-Velitski S, Bril R, Benayoun L, Munster M, Milsom C, Man S,
Blood. 2011 Jun 17. 118(12):3426-35.
 
Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation
2011
Ami Aronheim, PhD
Authors : Weidenfeld-Baranboim K, Koren L, Aronheim A.
Biochem J. 2011 Jun 15;436(3):661-9.
 
The heparanase system and tumor metastasis: is heparanase the seed and soil?
2011
Cancer Metastasis Rev. 2011 Jun;30(2):253-68. Review.
 
Antiangiogenic Antitumor Activity of HPMA Copolymer-Paclitaxel-Alendronate Conjugate on Breast Cancer Bone Metastasis Mouse Model.
2011
Yuval Shaked, PhD
Authors : Miller K, Eldar-Boock A, Polyak D, Segal E, Benayoun L, Shaked Y, Satchi-Fainaro R.
Mol Pharm. 2011 May 17. [Epub ahead of print]
 
The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.
2011
Karl Skorecki, MD
Authors : Rosset S, Tzur S, Behar DM, Wasser WG, Skorecki K.
Nat Rev Nephrol. 2011 May 3. [Epub ahead of print]
 
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.
2011
Israel Vlodavsky, PhD
Authors : Lerner I, Hermano E, Zcharia E, Rodkin D, Bulvik R, Doviner V, Rubinstein AM,
J Clin Invest. 2011 May 2;121(5):1709-21.
 
NF-κB activation by peroxynitrite through
2011
Abraham Z. Reznick, PhD
Authors : Gochman E, Mahajna J, Reznick AZ.
Anticancer Res. 2011 May; 31(5):1607-17.
 
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling.
2011
Gera Neufeld, PhD
Authors : Kigel B, Rabinowicz N, Varshavsky A, Kessler O, Neufeld G.
Blood. 2011 Aug 10. 118, 4285-4296
 
Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice.
2011
Israel Vlodavsky, PhD
Authors : Planer D, Metzger S, Zcharia E, Wexler ID, Vlodavsky I, Chajek-Shaul T.
PLoS One. 2011 Apr 4;6(4):e18370.
 
Nicotinic modulation of gene expression in osteoblast cells, MG-63.
2011
Bone. 2011 Apr 1;48(4):903-9.
 
Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances.
2011
Yuval Shaked, PhD
Authors : Kopeckova P, Shaked Y, Kopecek J, Satchi-Fainaro
Biomaterials. 2011 Mar 21. 32(19):4450-63.
 
Local Retention Versus Systemic Release of Soluble VEGF Receptor-1 Are Mediated by Heparin-Binding and Regulated by Heparanase.
2011
Israel Vlodavsky, PhD
Authors : Sela S, Natanson-Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E.
Circ Res. 2011 Mar 17. [Epub ahead of print]
 
Oxidation and female reproduction: the good, the bad and what's between.
2011
Abraham Z. Reznick, PhD
Authors : Harefuah. 2011 Mar;150(3):255-9
Wiener-Megnazi Z, Reznick AZ, Lahav-Baratz S, Shiloh H, Koifman M, Grach B, Arnon T, Avraham L, Auslander R, Dirnfeld M.
 
Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression
2011
Amir Orian, MD, PhD
Authors : Abed M, Barry KC, Kenyagin D, Koltun B, Phippen TM, Delrow JJ, Parkhurst SM, Orian A.
EMBO J. 2011 Feb 22. 30(7):1289-301
 
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
2011
Israel Vlodavsky, PhD
Authors : Shafat I, Ilan N, Zoabi S, Vlodavsky I, Nakhoul F.
PLoS One. 2011 Feb 22;6(2):e17312.
 
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels.
2011
PLoS One. 2011 Feb 22;6(2):e17312.
 
The heparanase system and tumor metastasis: is heparanase the seed and soil?
2011
Israel Vlodavsky, PhD
Authors : Arvatz G, Shafat I, Levy-Adam F, Ilan N, Vlodavsky I.
Cancer Metastasis Rev. 2011 Feb 11. [Epub ahead of print]
 
Cardiomyocytes generated from CPVT(D307H) patients are arrhythmogenic in response to β-adrenergic stimulation.
2011
Joseph Itskovitz-Eldor, MD, DSc
Authors : Novak A, Barad L, Zeevi-Levin N, Shick R, Shtreichman R, Lorber A, Itskovitz-Eldor J, Binah O.
J Cell Mol Med. 2011 [Epub ahead of print]
 
Degringolade a Drosophila STUbL is required for cellularization, sex determination, and early embryonic patterning
2011
Amir Orian, MD, PhD
Authors : Barry KC, Abed M, Kenyagin D, Werwie TR, Boiko O, Orian A, Parkhurst SM.
Development 138, 1759-1769.
 
Focal Adhesion Kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate
2011
Dale Frank, PhD
Authors : Fonar Y, Gutkovich YE, Root H, Malyarova A, Aamar E, Golubovskaya VM, Elias S, Elkouby YM, Frank D.
Mol. Biol. Cell 22, 2409-2421.
 
Induction of vasculogenesis by Gata transcription factors
2011
Tom Schultheiss, MD, PhD
Authors : Kamei CN, Kempf H, Yelin R, Daoud G, James RG, Lassar AB, Tabin CJ, Schultheiss TM.
Dev Biol 353, 29-37.
 
Keeping the CNS clear: glial phagocytic functions in Drosophila
2011
Estee Kurant, PhD
Authors : Kurant E
Glia 59, 1304-1311.
 
mRNA imprinting: Additional level in the regulation of gene expression.
2011
Mordechai (Motti) Choder, PhD
Authors : Choder M.
Cell Logist. 2011 Jan;1(1):37-40.
 
'Soft' tissue patterning - muscles and tendons of the limb take their form
2011
Peleg Hasson, PhD
Authors : Hasson P.
Developmental Dynamics 240, 1100-7.
 
Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of bPS integrin expression.
2011
Adi Salzberg, DSc
Authors : Egoz-Matia, N, Nachman, A, Halachmi, N, Toder, M, Klein, Y, Salzberg, A.
Dev Biol. 2011 351, 99-109
 
Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation
2011
Eyal Bengal, PhD
Authors : Alter J, Bengal E.
PLoS One. 2011;6(12):e29498
 
The STUbL protein Degringolade is a negative regulator of hairy-mediated Groucho-dependent repression
2011
Amir Orian, MD, PhD
Authors : Abed M, Barry KC, Kenyagin D, Koltun B, Phippen TP, Delrow JJ, Parkhurst SM, Orian A.
EMBO J. 30, 1289-1301.
 
Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium
2010
Ami Aronheim, PhD
Authors : Hasin T, Elhanani O, Abassi Z, Hai T, Aronheim A.
Basic Res Cardiol. 2010 106(2):175-87.
 
Nicotinic modulation of gene expression in osteoblast cells, MG-63.
2010
Michael Soudry, MD
Authors : Rothem DE, Rothem L, Dahan A, Eliakim R, Soudry M.
Bone. 2010 Dec 16. [Epub ahead of print]
 
Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target.
2010
Dan Hershko, MD
Authors : Hershko DD.
Future Oncol. 2010 Dec;6(12):1837-47.
 
Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus.
2010
Joseph Itskovitz-Eldor, MD, DSc
Authors : Novak A, Shtrichman R, Germanguz I, Segev H, Zeevi-Levin N, Fishman B, Mandel YE, Barad L, Domev H, Kotton D, Mostoslavsky G, Binah O, Itskovitz-Eldor J.
Cell Reprogram. 2010 Dec;12(6):665-78.
 
Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms
2010
Abraham Z. Reznick, PhD
Authors : Ruimi N, Petrova RD, Agbaria R, Sussan S, Wasser SP, Reznick AZ, Mahajna J.
Mol Biol Rep. 2010 Dec;37(8):3801-12.
 
Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element
2010
Israel Vlodavsky, PhD
Authors : Arvatz G, Barash U, Nativ O, Ilan N, Vlodavsky I.
FASEB J. 2010 Dec;24(12):4969-76.
 
The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.
2010
Tamar Kleinberger, PhD
Authors : Mittelman K, Ziv K, Maoz T, Kleinberger T.
PLoS One. 2010 Nov 22;5(11):e15539
 
RNA polymerase II subunits link transcription and mRNA decay to translation
2010
Mordechai (Motti) Choder, PhD
Authors : Harel-Sharvit L, Eldad N, Haimovich G, Barkai O, Duek L, Choder M.
Cell. 2010 Nov 12;143(4):552-63.
 
Oxidative parameters of embryo culture media may predict treatment outcome in in vitro fertilization: a novel applicable tool for improving embryo selection.
2010
Abraham Z. Reznick, PhD
Authors : Wiener-Megnazi Z, Shiloh H, Avraham L, Lahav-Baratz S, Koifman M, Reznick AZ, Auslender R, Dirnfeld M.
Fertil Steril. 2010 Nov 10. [Epub ahead of print]
 
The angiogenic profile of colorectal cancer patients following open or laparoscopic colectomy.
2010
Yuval Shaked, PhD
Authors : Voloshin T, Gingis-Velitski S, Shaked Y.
Cancer Biol Ther. 2010 Nov 10;10(7):686-8.
 
Effects of cigarette smoke on salivary protein tyrosine nitration.
2010
Abraham Z. Reznick, PhD
Authors : Weiner D, Khankin EV, Levy Y, Aizenbud D, Reznick AZ.
Eur J Med Res. 2010 Nov 4;15 Suppl 2:211-6.
 
Preclinical and clinical significance of heparanase in Ewing's sarcoma.
2010
Israel Vlodavsky, PhD
Authors : Shafat I, Ben-Arush MW, Issakov J, Meller I, Naroditsky I, Tortoteto M, Cassinelli G, Lanzi C, Pisano C, Ilan N, Vlodavsky I, Zunino F.
J Cell Mol Med. 15(9):1857-64.
 
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.
2010
Israel Vlodavsky, PhD
Authors : Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I.
FEBS J. 2010 Oct; 277(19):3890-903.
 
External fixation for the treatment of intra-articular fractures of the distal radius: short-term results.
2010
Michael Soudry, MD
Authors : Haddad M, Rubin G, Soudry M, Rozen N.
Isr Med Assoc J. 2010 Jul;12(7):406-9.
 
Functional properties of human embryonic stem cell-derived cardiomyocytes.
2010
Joseph Itskovitz-Eldor, MD, DSc
Authors : Zeevi-Levin N, Itskovitz-Eldor J, Binah O.
Crit Rev Eukaryot Gene Expr. 2010;20(1):51-9. Review.
 
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
2010
Israel Vlodavsky, PhD
Authors : Levy-Adam F, Feld S, Cohen-Kaplan V, Shteingauz A, Gross M, Arvatz G, Naroditsky I, Ilan N, Doweck I, Vlodavsky I.
J Biol Chem. 2010 Sep 3;285(36):28010-9.
 
Prognostic value of heparanase expression and cellular localization in oral cancer.
2010
Israel Vlodavsky, PhD
Authors : Leiser Y, Abu-El-Naaj I, Sabo E, Akrish S, Ilan N, Ben-Izhak O, Peled M, Vlodavsky I.
Head Neck. 33(6):871-7.
 
Studying MAP Kinase Pathways During Early Development of Xenopus laevis.
2010
Eyal Bengal, PhD
Authors : Keren A, Bengal E.
Methods Mol Biol. 2010;661:409-20.
 
Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII
2010
Israel Vlodavsky, PhD
Authors : Nadir Y, Brenner B, Fux L, Shafat I, Attias J, Vlodavsky I.
Haematologica. 95(11):1927-34
 
Tumorigenic and adhesive properties of heparanase
2010
Israel Vlodavsky, PhD
Authors : Levy-Adam F, Ilan N, Vlodavsky I.
Semin Cancer Biol. 20(3):153-60.
 
Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.
2010
Dan Hershko, MD
Authors : Bar-On O, Shapira M, Skorecki K, Hershko A, Hershko DD.
Cell Cycle. 2010 May 15;9(10):1986-9.
 
Limb muscle and tendon patterning requires timed activity of Tbx4 and Tbx5
2010
Peleg Hasson, PhD
Authors : Hasson P, DeLaurier A, Bennett M, Grigorieva E, Naiche LA, Papaioannou VE, Mohun TJ, Logan M.
Developmental Cell 18, 148-56.
 
Mesodermal Wnt signaling organizes the neural plate via Meis3
2010
Dale Frank, PhD
Authors : Elkouby YM, Elias S, Casey EM, Blythe SA, Tsabar N, Klein PS, Root H, Liu KJ, Frank D.
Development 137, 1531-1541.
 
Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform
2010
Gera Neufeld, PhD
Authors : Casazza A, Kigel B, Maione F, Capparuccia L, Kessler O, Giraudo E, Mazzone M, Neufeld G, Tamagnone L.
EMBO Mol. Med. 4, 234-250
 
Predictive Potential of Angiogenic Growth Factors and Circulating Endothelial Cells in Breast Cancer Patients Receiving Metronomic Chemotherapy Plus Bevacizumab
2009
Yuval Shaked, PhD
Authors : Calleri A‭, ‬Bono A‭, ‬Bagnardi V‭, ‬Quarna J‭, ‬Mancuso P‭, ‬Rabascio C‭, ‬Dellapasqua S‭,‬ Campagnoli E‭, ‬Shaked Y‭, ‬Goldhirsch A‭, ‬Colleoni M‭, ‬Bertolini F‭.
Clin Cancer Res‭. ‬2009‭ ‬Dec 15‭;‬15‭(‬24‭):‬7652-7657‭
 
A novel human heparanase splice variant‭, ‬T5‭, ‬endowed with rotumorigenic characteristics
2009
Israel Vlodavsky, PhD
Authors : Barash U‭, ‬Cohen-Kaplan V‭, ‬Arvatz G‭, ‬Gingis-Velitski S‭, ‬Levy-Adam F‭, ‬Nativ O‭,‬ Shemesh R‭, ‬Ayalon-Sofer M‭, ‬Ilan N‭, ‬Vlodavsky I‭. ‬
FASEB J‭. . [‬Epub ahead‭ ‬of print‭]
 
The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe
2009
Adi Salzberg, DSc
Authors : Klein, Y., Halachmi, N., Egoz-Matia,N., Toder, M., and Salzberg, A.
Dev Biol. 337, 458-470.
 
Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development
2009
Dale Frank, PhD
Authors : Gutkovich Y, Ofir R, Elkouby YM, Dibner C, Gefen A, Elias S, Frank D.
Dev Biol. 338(1):50-62.
 
A simple technique for the placement of Schanz screws into bone using minimal radiologic control
2009
Michael Soudry, MD
Authors : Lerner A, Akinyoola AL, Soudry M.
Trop Doct. 2009 Oct 22. [Epub ahead of print]
 
Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents
2009
Yuval Shaked, PhD
Authors : Shaked Y, Tang T, Woloszynek J, Daenen LG, Man S, Xu P, Cai SR, Arbeit JM, Voest EE, Chaplin DJ, Smythe J, Harris A, Nathan P, Judson I, Rustin G, Bertolini F, Link DC, Kerbel RS.
Cancer Res. 2009 69:7524-8.
 
Heparanase: busy at the cell surface
2009
Israel Vlodavsky, PhD
Authors : Fux L, Ilan N, Sanderson RD, Vlodavsky I.
Trends Biochem Sci. 2009 34, 511-9.
 
Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/CREB pathway
2009
Eyal Bengal, PhD
Authors : Keren-Politansky A, Keren A, Bengal E.
Dev Biol. 2009 Sep 15. 335, 374-384.
 
Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression
2009
Israel Vlodavsky, PhD
Authors : Brun R, Naroditsky I, Waterman M, Ben-Izhak O, Groisman G, Ilan N, Vlodavsky I.
Mod Pathol. 22(12):1548-54.
 
Bone marrow derived cells in tumor angiogenesis and growth: are they the good, the bad or the evil?
2009
Yuval Shaked, PhD
Authors : Shaked Y, Voest EE.
Biochim Biophys Acta. 2009 1796(1):1-4.
 
Patients aged 80‭ ‬and older undergoing orthopedic or urologic surgery‭: ‬a prospective study‭ ‬focusing on perioperative morbidity and mortality
2009
Michael Soudry, MD
Authors : Peled E‭, ‬Keren Y‭, ‬Halachmi S‭, ‬Soudry M‭, ‬Zinman C‭, ‬Kats Y‭, ‬Barak M‭.
Gerontology‭.‬ 2009‭;‬55‭(‬5‭):‬517-22‭
 
Transplanted blood-derived endothelial progenitor cells (EPC) enhance bridging of sheep tibia critical size defects
2009
Michael Soudry, MD
Authors : Rozen N, Bick T, Bajayo A, Shamian B, Schrift-Tzadok M, Gabet Y, Yayon A, Bab I, Soudry M, Lewinson D.
Bone. 2009 Aug 6.
 
DamID: A Methylation-Based Chromatin Profiling Approach
2009
Amir Orian, MD, PhD
Authors : Orian A, Abed M, Kenyagin-Karsenti D, Boico O.
Methods Mol Biol. 2009;567:155-69.
 
Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells
2009
Abraham Z. Reznick, PhD
Authors : Bar-Shai, M., Reznick, A. Z.
Free Radic Biol Med 40, 2112-2125.
 
Long-term results after Ilizarov treatment for severe high-energy injuries of the elbow
2009
Michael Soudry, MD
Authors : Fodor L‭, ‬Ullmann Y‭, ‬Soudry M‭, ‬Lerner A‭.
J Trauma‭. ‬2009 Jun;66‭(‬6‭):‬1647-52‭.
 
Plasma heparanase as a significant marker of treatment response in children with Hodgkin lymphoma: pilot study
2009
Israel Vlodavsky, PhD
Authors : Ben Arush MW, Shafat I, Ben Barak A, Shalom RB, Vlodavsky E, Ilan N.
Pediatr Hematol Oncol. 2009 Jun;26(4):157-64.
 
Nicotine modulates bone metabolism-associated gene expression in osteoblast cells
2009
Michael Soudry, MD
Authors : Rothem DE‭, ‬Rothem L‭, ‬Soudry M‭, ‬Dahan A‭, ‬Eliakim R‭.
J Bone Miner Metab‭.‬ 2009‭;‬27‭(‬5‭):‬555-61
 
Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway
2009
Abraham Z. Reznick, PhD
Authors : Petrova RD, Mahajna J, Wasser SP, Ruimi N, Denchev CM, Sussan S, Nevo E, Reznick AZ.
Mol Biol Rep. 2009 Apr;36(4):737-44.
 
The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3
2009
Ami Aronheim, PhD
Authors : Weidenfeld-Baranboim K, Hasin T, Darlyuk I, Heinrich R, Elhanani O, Pan J, Yokoyama KK, Aronheim A.
Nucleic Acids Res. 2009 Apr;37(7):2194-203.
 
The Expression and Prognostic Significance of Cks1 in Salivary Cancer
2009
Dan Hershko, MD
Authors : Nagler RM, Ben-Izhak O, Ostrovsky D, Golz A, Hershko DD.
Cancer Invest. 2009 Mar 23:1. [Epub ahead of print]
 
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling
2009
Israel Vlodavsky, PhD
Authors : Fux L, Feibish N, Cohen-Kaplan V, Gingis-Velitski S, Feld S, Geffen C, Vlodavsky I, Ilan N.
Cancer Res. 2009 Mar 1;69(5):1758-67.
 
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis
2009
Israel Vlodavsky, PhD
Authors : Nasser NJ, Avivi A, Shafat I, Edovitsky E, Zcharia E, Ilan N, Vlodavsky I, Nevo E.
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2253-8.
 
The evolutionary theories of aging revisited‭ -‬a mini-review
2009
Abraham Z. Reznick, PhD
Authors : Ljubuncic P‭, ‬Reznick AZ‭.
Gerontology‭. ‬2009‭;‬55‭(‬2‭):‬205-16‭. ‬Epub 2009‭ ‬Feb 7
 
A p38 MAPK-CREB pathway functions to pattern mesoderm in Xenopus
2008
Eyal Bengal, PhD
Authors : Keren A, Keren-Politansky A, Bengal E.
Dev Biol. 2008 Oct 1;322(1):86-94.
 
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells
2008
Gera Neufeld, PhD
Authors : Kigel B, Varshavsky A, Kessler O, Neufeld G.
PLoS ONE. 2008 Sep 26;3(9):e3287
 
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents
2008
Yuval Shaked, PhD
Authors : Shaked, Y., Henke, E., Roodhart, J. M. L., Mancuso, P., Langenberg, M. H. G., Colleoni, M., Daenen, L. G., Man, S., Xu, P., Emmenegger, U., Tang, T., Zhu, Z., Witte, L., Streiter, R. M., Bertolini, F., Voest, E. E., Benezra, R., Kerbel, R. S.
Cancer Cell 14, 263-273.
 
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival
2008
Israel Vlodavsky, PhD
Authors : Cohen E, Doweck I, Naroditsky I, Ben-Izhak O, Kremer R, Best LA, Vlodavsky I, Ilan N.
Cancer. 2008 Sep 1;113(5):1004-11
 
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases
2008
Gera Neufeld, PhD
Authors : Varshavsky A, Kessler O, Abramovitch S, Kigel B, Zaffryar S, Akiri G, Neufeld G.
Cancer Res. 2008 Sep 1;68(17):6922-31
 
Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor
2008
Eyal Bengal, PhD
Authors : Alter J, Rozentzweig D, Bengal E
J Biol Chem. 2008 Aug 22;283(34):23224-34.
 
Heparanase: one molecule with multiple functions in cancer progression
2008
Israel Vlodavsky, PhD
Authors : Vlodavsky I, Elkin M, Abboud-Jarrous G, Levi-Adam F, Fuks L, Shafat I, Ilan N.
Connect Tissue Res. 2008;49(3):207-10.
Overexpression of Skp2 is associated with resistance to preoperative doxorubicin - based chemotherapy in primary breast cancer
2008
Dan Hershko, MD
Authors : Davidovich S, Ben-Izhak O, Shapira M, Futerman B, Hershko DD.
Breast Cancer Res. 2008 Jul 21;10(4):R63 [Epub ahead of print] PMID: 18644126
TRE-dependent transcription activation by JDP2-CHOP10 association
2008
Ami Aronheim, PhD
Authors : Weidenfeld-Baranboim K, Bitton-Worms K, Aronheim A.
Nucleic Acids Res. 2008 Jun;36(11):3608-19.
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
2008
Gera Neufeld, PhD
Authors : Neufeld G, Kessler O.
Nat Rev Cancer. 2008 Aug;8(8):632-45. Epub 2008 Jun 26. Review
 
Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes
2008
Mordechai (Motti) Choder, PhD
Authors : Goler-Baron V, Selitrennik M, Barkai O, Haimovich G, Lotan R, Choder M.
Genes Dev. 2008 Aug 1;22(15):2022-7
 
Chromosomal binding sites of the homeotic cofactor Homothorax
2008
Adi Salzberg, DSc
Authors : Cohen L, Salzberg A.
Mol Genet Genomics. ;280(1):73-81.
 
Left-sided perforated acute appendicitis in an adult with midgut malrotation: the role of computed tomography
2008
Dan Hershko, MD
Authors : Israelit S, Brook OR, Nira BR, Guralnik L, Hershko D.
Emerg Radiol. 2008 Jul 19. [Epub ahead of print]
 
Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer.
2008
Dan Hershko, MD
Authors : Hershko DD
Cancer. 2008 Apr 1;112(7):1415-24. Review.
 
Exercise and immobilization in aging animals: The involvement of oxidative stress and NF-kB activation
2008
Abraham Z. Reznick, PhD
Authors : Bar-Shai, M., Carmeli, E., Ljubuncic, P., Reznick, A. Z.
Free Radic Biol Med 44, 202-214.
 
Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells.
2008
Israel Vlodavsky, PhD
Authors : Nadir Y, Brenner B, Gingis-Velitski S, Levy-Adam F, Ilan N, Zcharia E, Nadir E
Thromb Haemost. 2008 Jan;99(1):133-41.
 
Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons
2008
Estee Kurant, PhD
Authors : Kurant E, Axelrod S, Leaman D, Gaul U.
Cell 133, 498-509.
 
Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells.
2007
Dan Hershko, MD
Authors : Bar-On O, Shapira M
Anticancer Drugs. 2007 Nov;18(10):1113-21.
 
Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes.
2007
Ofer Binah, PhD  |   Joseph Itskovitz-Eldor, MD, DSc
Authors : Dolnikov K, Sadan O, Shilkrut M, Zeevi-Levin N, Amit M, Danon A.
J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S192-6.
 
Fracture repair: Modulation of fracture-callus and mechanical properties by sequential application of IL-6 following PTH 1-34 or PTH 28-48
2007
Michael Soudry, MD
Authors : Rozen, N., Lewinson, D., Bick, T., Jacob, C. Z., Soudry, M.
Bone 41, 437-445.
 
Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells.
2007
Dan Hershko, MD
Authors : Egozi D, Shapira M, Paor G, Ben-Izhak O, Skorecki K
FASEB J. 2007 Sep;21(11):2807-17.
 
Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis.
2007
Gera Neufeld, PhD
Authors : Guttmann-Raviv N, Shraga-Heled N, Varshavsky A, Guimaraes-Sternberg C, Kessler O.
. J Biol Chem. 2007 Sep 7;282(36):26294-305.
 
Additional sex combs affects antennal development by means of spatially restricted repression of Antp and Wg.
2007
Adi Salzberg, DSc
Authors : Halachmi N, Schulze KL, Inbal A.
Dev Dyn. 2007 Aug;236(8):2118-30.
 
Antiangiogenic strategies on defense: on the possibility of blocking rebounds by the tumor vasculature after chemotherapy
2007
Yuval Shaked, PhD
Authors : Shaked, Y., Kerbel, R. S.
Cancer Res 67, 7055-7058.
 
Role of bone regeneration and turnover modulators in control of fracture
2007
Michael Soudry, MD
Authors : Rozen, N., Lewinson, D., Bick, T., Meretyk, S., Soudry, M.
Crit Rev Eukaryot Gene Expr 17, 197-213.
 
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
2007
Ami Aronheim, PhD
Authors : Weisz Hubsman M, Volinsky N, Manser E, Yablonski D, Aronheim A.
Biochem J. 2007 Jun 15;404(3):487-97
 
Safety of elective hand surgery following axillary lymph node dissection for breast cancer.
2007
Dan Hershko, MD
Authors : Stahl S.
Breast J. 2007 May-Jun;13(3):287-90.
 
Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor.
2007
Gera Neufeld, PhD
Authors : Shraga-Heled N, Kessler O, Prahst C, Kroll J, Augustin H
FASEB J. 2007 Mar;21(3):915-26.
Conceptual modeling of biological systems: the mRNA lifecycle as a case in point
2007
Mordechai (Motti) Choder, PhD
Authors : Dori, D, Choder, M.
PLoS One, 2, e872
 
Healing of critical-sized bone defects by endothelial progenitor cells
2007
Michael Soudry, MD
Authors : Lewinson, D., Rozen, N., Bick, T., Yayon, A., Shemian, B., Soudry, M.
J Bone Miner Res 22, s234.
 
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.
2007
Israel Vlodavsky, PhD
Authors : Ilan N, Naggi A, Casu B.
Curr Pharm Des. 2007;13(20):2057-73.
 
Semaphorin signaling in vascular and tumor biology.
2007
Gera Neufeld, PhD
Authors : Lange T, Varshavsky A, Kessler O.
Adv Exp Med Biol. 2007;600:118-31. Review.
 
Tbx5 is dispensable for forelimb outgrowth
2007
Peleg Hasson, PhD
Authors : Hasson P, Del Bouno J, Logan M.
Development 134, 85-92.
 
The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.
2007
Mordechai (Motti) Choder, PhD
Authors : Lotan, R Goler Bar-On, V., Duek, L., Haimovitz, G., Choder, M.
J. Cell Biol. 178, 1133-1143.
 
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
2006
Tom Schultheiss, MD, PhD
Authors : Wu, S. M., Fujiwara, Y., Cibulsky, S. M., Clapham, D. E., Lien, C., Schultheiss, T. M., Orkin, S. H.
Cell 127, 1137-1150.
 
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival.
2006
Israel Vlodavsky, PhD
Authors : Doweck I, Kaplan-Cohen V, Naroditsky I, Sabo E, Ilan N, Vlodavsky I.
Neoplasia. 2006 Dec;8(12):1055-61.
 
Nucleocytoplasmic shuttling of the Rpb4p and Rpb7p subunits of Saccharomyces cerevisiae RNA polymerase II by two pathways.
2006
Mordechai (Motti) Choder, PhD
Authors : Selitrennik M, Duek L, Lotan R, Choder M.
Eukaryot Cell. 2006 Dec;5(12):2092-103
 
A new targeting approach for breast cancer gene therapy using the Heparanase promoter.
2006
Israel Vlodavsky, PhD
Authors : Breidenbach M, Rein DT, Schondorf T, Khan KN, Herrmann I, Schmidt T, Reynolds PN, Vlodavsky I, Haviv YS, Curiel DT.
Cancer Lett. 2006 Aug 18;240(1):114-22.
Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer.
2006
Dan Hershko, MD
Authors : Shapira M, Ben-Izhak O, Slotky M, Goldin O, Lahav-Baratz S, Hershko DD.
J Urol. 2006 Nov;176(5):2285-9.
 
Heparanase induces tissue factor expression in vascular endothelial and cancer cells.
2006
Israel Vlodavsky, PhD
Authors : Nadir Y, Brenner B, Zetser A, Ilan N, Shafat I, Zcharia E, Goldshmidt O, Vlodavsky I.
J. Thromb Haemost. 2006 Nov;4(11):2443-51.
 
Sources, derivation, and culture of human embryonic stem cells.
2006
Semin Reprod Med. 2006 Nov;24(5):298-303.
A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis.
2006
Mordechai (Motti) Choder, PhD
Authors : Topaz O, Indelman M, Chefetz I, Geiger D, Metzker A, Altschuler Y, Choder M, Bercovich D, Uitto J, Bergman R, Richard G, Sprecher E.
Am J Hum Genet. 2006 Oct;79(4):759-64.
 
The role of basic leucine zipper protein-mediated transcription in physiological and pathological myocardial hypertrophy.
2006
Ami Aronheim, PhD
Authors : Kehat I, Hasin T, Aronheim A.
Ann N Y Acad Sci. 2006 Oct;1080:97-109.
 
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
2006
Yuval Shaked, PhD
Authors : Shaked, Y., Ciarrocchi, A., Franco, M., Lee, C. R., Man, S., Cheung, A. M., Hicklin, D. J., Chaplin, D., Foster, F. S., Benezra, R., Kerbel, R. S.
Science 313, 1785-1787.
 
Prognostic role of p27Kip1 deregulation in colorectal cancer.
2006
Dan Hershko, MD
Authors : Hershko DD, Shapira M.
Cancer. 2006 Aug 15;107(4):668-75. Review.
 
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells
2006
Tom Schultheiss, MD, PhD
Authors : James, R. G., Kamei, C. N., Wang, Q., Jiang, R., Schultheiss, T. M.
Development 133, 2995-3004.
 
The mTOR inhibitor rapamycin downregulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
2006
Dan Hershko, MD
Authors : Shapira M, Kakiashvili E, Rosenberg T, Hershko DD.
Breast Cancer Res. 2006 Jul 19;8(4):R46 [Epub ahead of print] PMID: 16859513
 
Tumor suppressor p53 regulates heparanase gene expression.
2006
Israel Vlodavsky, PhD
Authors : Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I.
Oncogene. 2006 Jun 29;25(28):3939-47
Is mechanical bowel preparation mandatory for left-sided colonic anastomosis? Results of a prospective randomized trial.
2006
Dan Hershko, MD
Authors : Zmora O, Mahajna A, Bar-Zakai B, Hershko D, Shabtai M, Krausz MM, Ayalon A.
Tech Coloproctol. 2006 Jun 19; [Epub ahead of print] PMID: 16773286
Halofuginone inhibits NF-{kappa}B and p38 MAPK in activated T cells.
2006
Israel Vlodavsky, PhD
Authors : Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A.
J Leukoc Biol. 2006 80(2):399-406.
Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Schwanke K, Wunderlich S, Reppel M, Winkler ME, Matzkies M, Groos S, Itskovitz-Eldor J, Simon AR, Hescheler J, Haverich A, Martin U.
Stem Cells. 2006 Jun;24(6):1423-32. Epub 2006 Mar 16. PMID: 16543489
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.
2006
Israel Vlodavsky, PhD
Authors : Kram V, Zcharia E, Yacoby-Zeevi O, Metzger S, Chajek-Shaul T, Gabet Y, Muller R, Vlodavsky I, Bab I.
J Cell Physiol. 2006 Jun;207(3):784-92.
Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro.
2006
Israel Vlodavsky, PhD
Authors : Rouet V, Meddahi-Pelle A, Miao HQ, Vlodavsky I, Caruelle JP, Barritault D.
J Biomed Mater Res A. 2006 Jun 1; [Epub ahead of print] PMID: 16741978
Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation.
2006
Ami Aronheim, PhD
Authors : Kehat I, Heinrich R, Ben-Izhak O, Miyazaki H, Gutkind JS, Aronheim A.
Cardiovasc Res. 2006 Jun 1;70(3):543-54.
Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.
2006
Israel Vlodavsky, PhD
Authors : Doviner V, Maly B, Kaplan V, Gingis-Velitski S, Ilan N, Vlodavsky I, Sherman Y.
Mod Pathol. 2006 Jun;19(6):878-88. PMID: 16607375
Translocation of active heparanase to cell surface regulates degradation of extracellular matrix heparan sulfate upon transmigration of mature monocyte-derived dendritic cells.
2006
Israel Vlodavsky, PhD
Authors : Benhamron S, Nechushtan H, Verbovetski I, Krispin A, Abboud-Jarrous G, Zcharia E, Edovitsky E, Nahari E, Peretz T, Vlodavsky I, Mevorach D.
J Immunol. 2006 Jun 1;176(11):6417-24. PMID: 16709798
Role of endothelial heparanase in delayed-type hypersensitivity.
2006
Israel Vlodavsky, PhD
Authors : Edovitsky E, Lerner I, Zcharia E, Peretz T, Vlodavsky I, Elkin M.
Blood. 2006 May 1;107(9):3609-16.
The "Sentinel Chain": a new concept for prediction of axillary node status in breast cancer patients.
2006
Dan Hershko, MD
Authors : Carmon M, Olsha O, Schecter WP, Raveh D, Reinus C, Hershko DD, Beller U, Golomb E.
Breast Cancer Res Treat. 2006 Apr 27; [Epub ahead of print] PMID: 16642272
The p38 MAPK signaling pathway: A major regulator of skeletal muscle development.
2006
Eyal Bengal, PhD
Authors : Keren A, Tamir Y, Bengal E.
Mol Cell Endocrinol. 2006 16644098 252(1-2):224-30.
Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cells survival and migration.
2006
Gera Neufeld, PhD
Authors : Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P, Herbert JM, Bono F.
Blood. 2006 Apr 18; [Epub ahead of print] PMID: 16621967
Chromatin profiling, DamID and the emerging landscape of gene expression.
2006
Amir Orian, MD, PhD
Authors : Orian A.
Curr Opin Genet Dev. 2006 Apr;16(2):157-64. Epub 2006 Feb 28. Review. PMID: 16503134
Heparanase promotes growth, angiogenesis and survival of primary breast tumors.
2006
Israel Vlodavsky, PhD
Authors : Cohen I, Pappo O, Elkin M, San T, Bar-Shavit R, Hazan R, Peretz T, Vlodavsky I, Abramovitch R.
Int J Cancer. 2006 Apr 1;118(7):1609-17.
An ELISA method for the detection and quantification of human heparanase.
2006
Israel Vlodavsky, PhD
Authors : Shafat I, Zcharia E, Nisman B, Nadir Y, Nakhoul F, Vlodavsky I, Ilan N.
Biochem Biophys Res Commun. 2006 Mar 24;341(4):958-63.
Laparoscopic diagnostic peritoneal lavage (L-DPL): A method for evaluation of penetrating abdominal stab wounds.
2006
Dan Hershko, MD
Authors : Krausz MM, Abbou B, Hershko DD, Mahajna A, Duek DS, Bishara B, Israelit SH.
World J Emerg Surg. 2006 Mar 24;1:3. PMID: 16759402
Sentinel lymph node biopsy in thin melanoma patients.
2006
Dan Hershko, MD
Authors : Hershko DD, Robb BW, Lowy AM, Ahmad SA, Ramadas GH, Soldano DA, Sussman JJ.
J Surg Oncol. 2006 Mar 15;93(4):279-85. PMID: 16496355
Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.
2006
Israel Vlodavsky, PhD
Authors : Nasser NJ, Sarig G, Brenner B, Nevo E, Goldshmidt O, Zcharia E, Li JP, Vlodavsky I.
J Thromb Haemost. 2006 Mar;4(3):560-5.
Peroxynitrite induces an alternative NF-kB activation pathway in L8 rat myoblasts
2006
Abraham Z. Reznick, PhD
Authors : Bar-Shai, M., Reznick, A. Z.
Antioxid Redox Signal 8, 639-652.
 
Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Dolnikov K, Shilkrut M, Zeevi-Levin N, Gerecht-Nir S, Amit M, Danon A, Itskovitz-Eldor J, Binah O.
Stem Cells. 2006 Feb;24(2):236-45. Epub 2005 Dec 1. PMID: 16322641
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation.
2006
Israel Vlodavsky, PhD
Authors : Zetser A, Bashenko Y, Edovitsky E, Levy-Adam F, Vlodavsky I, Ilan N.
Cancer Res. 2006 Feb 1;66(3):1455-63.
The neuropilins and their role in tumorigenesis and tumor progression.
2006
Gera Neufeld, PhD
Authors : Guttmann-Raviv N, Kessler O, Shraga-Heled N, Lange T, Herzog Y, Neufeld G.
Cancer Lett. 2006 Jan 8;231(1):1-11. Review. PMID: 16356825
Chromatin profiling, DamID and the emerging landscape of gene expression
2006
Curr Opin Genet Dev. 16, 157-64.
 
Derivation and maintenance of human embryonic stem cells.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Amit M, Itskovitz-Eldor J.
Methods Mol Biol. 2006;331:43-53.
Feeder-free culture of human embryonic stem cells.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Goldberg-Cohen I, Beck G, Ziskind A, Itskovitz-Eldor J.
Methods Enzymol. 2006;420:37-49.
 
Maintenance of human embryonic stem cells in animal serum- and feeder layer-free culture conditions.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Amit M, Itskovitz-Eldor J.
Methods Mol Biol. 2006;331:105-13. PMID: 16881512
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.
2006
Israel Vlodavsky, PhD
Authors : Ilan N, Elkin M,Vlodavsky I.
Int J Biochem Cell Biol.2006;38(12):2018-39.
 
The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
2006
Breast Cancer Res. 2006;8(4):R46.
 
Tissue engineering using human embryonic stem cells.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Cohen S, Leshanski L.
Methods Enzymol. 2006;420:303-15.
 
Vascular cells.
2006
Joseph Itskovitz-Eldor, MD, DSc
Authors : Goldberg-Cohen I, Beck G, Ziskind A, Itskovitz-Eldor J.
Methods Enzymol. 2006;418:252-66
 
The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs.
2005
Mordechai (Motti) Choder, PhD
Authors : Lotan R, Bar-On VG, Harel-Sharvit L, Duek L, Melamed D, Choder M.
Genes Dev. 2005 Dec 15;19(24):3004-16. PMID: 16357218
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.
2005
Israel Vlodavsky, PhD
Authors : Nasser NJ, Nevo E, Shafat I, Ilan N, Vlodavsky I, Avivi A.
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15161-6.
Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells.
2005
Israel Vlodavsky, PhD
Authors : Eshel R, Ben-Zaken O, Vainas O, Nadir Y, Minucci S, Polliack A, Naparstek E, Vlodavsky I, Katz BZ.
Biochem Biophys Res Commun. 2005 Oct 7;335(4):1115-22.
Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.
2005
Gera Neufeld, PhD
Authors : Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, Izhak OB, Neufeld G.
J Hepatol. 2005 Sep;43(3):499-507. PMID: 16023247
CD133-positive hematopoietic stem cell "stemness" genes contain many genes mutated or abnormally expressed in leukemia.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Toren A, Bielorai B, Jacob-Hirsch J, Fisher T, Kreiser D, Moran O, Zeligson S, Givol D, Yitzhaky A, Itskovitz-Eldor J, Kventsel I, Rosenthal E, Amariglio N, Rechavi G.
Stem Cells. 2005 Sep;23(8):1142-53. PMID: 16140871
Bowel preparation is associated with spillage of bowel contents in colorectal surgery.
2005
Dan Hershko, MD
Authors : Mahajna A, Krausz M, Rosin D, Shabtai M, Hershko D, Ayalon A, Zmora O.
Dis Colon Rectum. 2005 Aug;48(8):1626-31. PMID: 15981063
Nucleofection of human embryonic stem cells.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Siemen H, Nix M, Endl E, Koch P, Itskovitz-Eldor J, Brustle O.
Stem Cells Dev. 2005 Aug;14(4):378-83. PMID: 16137226
Society's contribution to assisted reproductive technology abuse.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Kol S, Itskovitz-Eldor J.
Hum Reprod. 2005 Aug;20(8):2362. No abstract available. PMID: 16024541
Homodimeric MyoD preferentially binds tetraplex structures of regulatory sequences of muscle-specific genes.
2005
Eyal Bengal, PhD
Authors : Etzioni S, Yafe A, Khateb S, Weisman-Shomer P, Bengal E, Fry M.
J Biol Chem. 2005 Jul 22;280(29):26805-12.
The expression of the ubiquitin ligase subunit Cks1 in human breast cancer.
2005
Dan Hershko, MD
Authors : Slotky M, Shapira M, Ben-Izhak O, Linn S, Futerman B, Tsalic M, Hershko DD.
Breast Cancer Res. 2005;7(5):R737-44. Epub 2005 Jul 19. PMID: 16168119
Transanal endoscopic microsurgery for rectal cancer.
2005
Dan Hershko, MD
Authors : Duek SD, Krausz MM, Hershko DD.
Isr Med Assoc J. 2005 Jul;7(7):435-8. PMID: 16011058
Molecular analysis of cardiomyocytes derived from human embryonic stem cells.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Segev H, Kenyagin-Karsenti D, Fishman B, Gerecht-Nir S, Ziskind A, Amit M, Coleman R, Itskovitz-Eldor J.
Dev Growth Differ. 2005 Jun;47(5):295-306. PMID: 16026538
No evidence for infection of human embryonic stem cells by feeder cell-derived murine leukemia viruses.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Amit M, Winkler ME, Menke S, Bruning E, Buscher K, Denner J, Haverich A, Itskovitz-Eldor J, Martin U.
Stem Cells. 2005 Jun-Jul;23(6):761-71. PMID: 15917472
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis.
2005
Israel Vlodavsky, PhD
Authors : Li JP, Galvis ML, Gong F, Zhang X, Zcharia E, Metzger S, Vlodavsky I, Kisilevsky R, Lindahl U.
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6473-7.
Heparanase processing by lysosomal/endosomal protein preparation
2005
Israel Vlodavsky, PhD
Authors : Cohen E, Atzmon R, Vlodavsky I, Ilan N.
FEBS Lett. 2005 Apr 25;579(11):2334-8.
Heparanase regulates murine hair growth.
2005
Israel Vlodavsky, PhD
Authors : Zcharia E, Philp D, Edovitsky E, Aingorn H, Metzger S, Kleinman HK, Vlodavsky I, Elkin M.
Am J Pathol. 2005 Apr;166(4):999-1008.
Segregation of arterial and venous markers in subpopulations of blood islands before vessel formation.
2005
Gera Neufeld, PhD
Authors : Herzog Y, Guttmann-Raviv N, Neufeld G.
Dev Dyn. 2005 Apr;232(4):1047-55. PMID: 15739224
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma.
2005
Dan Hershko, MD
Authors : Shapira M, Ben-Izhak O, Linn S, Futerman B, Minkov I, Hershko DD.
Cancer. 2005 Apr 1;103(7):1336-46. PMID: 15717322
The role of heparanase in lymph node metastatic dissemination: dynamic contrast-enhanced MRI of Eb lymphoma in mice.
2005
Israel Vlodavsky, PhD
Authors : Dafni H, Cohen B, Ziv K, Israely T, Goldshmidt O, Nevo N, Harmelin A, Vlodavsky I, Neeman M.
Neoplasia. 2005 Mar;7(3):224-33.
Decreased expression of heparanase in glioblastoma multiforme.
2005
Israel Vlodavsky, PhD
Authors : Ueno Y, Yamamoto M, Vlodavsky I, Pecker I, Ohshima K, Fukushima T.
J Neurosurg. 2005 Mar;102(3):513-21.
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.
2005
Ami Aronheim, PhD
Authors : Frankel P, Aronheim A, Kavanagh E, Balda MS, Matter K, Bunney TD, Marshall CJ.
EMBO J. 2005 Jan 12;24(1):54-62.
Bmp signals promote gene expression in the intermediate mesoderm in a dose-dependent, cell-autonomous, and translation-dependent manner
2005
Tom Schultheiss, MD, PhD
Authors : James, R. G., Schultheiss, T. M.
Dev Bio 288, 113-125.
 
Functional properties of human embryonic stem cell-derived cardiomyocytes.
2005
Joseph Itskovitz-Eldor, MD, DSc
Authors : Dolnikov K, Shilkrut M, Zeevi-Levin N, Danon A, Gerecht-Nir S, Itskovitz-Eldor J, Binah O.
Ann N Y Acad Sci. 2005 Jun;1047:66-75. PMID: 16093485
Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.
2005
Amir Orian, MD, PhD
Authors : Orian A, Grewal SS, Knoepfler PS, Edgar BA, Parkhurst SM, Eisenman RN.
Cold Spring Harb Symp Quant Biol. 2005;70:299-307.
 
HVEGF165 increases survival of transplanted hepatocytes within portal radicles: suggested mechanism for early cell engraftment.
2005
Gera Neufeld, PhD
Authors : Shani-Peretz H, Tsiperson V, Shoshani G, Veitzman E, Neufeld G, Baruch Y.
Cell Transplant. 2005;14(1):49-57. PMID: 15789662
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.
2005
Israel Vlodavsky, PhD
Authors : Levy-Adam F, Abboud-Jarrous G, Guerrini M, Beccati D, Vlodavsky I, Ilan N.
J Biol Chem ;280:20457-20466.
 
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.
2005
Amir Orian, MD, PhD
Authors : Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA.
Nat Cell Biol ;7:295-302.
 
p38 MAP kinase regulates the expression of XMyf5 and affects distinct myogenic programs during Xenopus development.
2005
Eyal Bengal, PhD  |   Dale Frank, PhD
Authors : Keren A, Bengal E, Frank D.
Dev Biol;288:73-86.
 
PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I.
2005
Israel Vlodavsky, PhD
Authors : Navab R, Aingorn H, Fallavollita L, Sallon S, Mechoulam R, Ginsburg I, Vlodavsky I, Brodt P.
Inflammopharmacology. 2004;12(4):373-89.
Semaphorins in cancer.
2005
Gera Neufeld, PhD
Authors : Neufeld G, Shraga-Heled N, Lange T, Guttmann-Raviv N, Herzog Y, Kessler O.
Front Biosci. 2005 Jan 1;10:751-60. Print 2005 Jan 1. PMID: 15569615
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase.
2005
Israel Vlodavsky, PhD
Authors : Abboud-Jarrous G, Rangini-Guetta Z, Aingorn H, Atzmon R, Elgavish S, Peretz T, and Vlodavsky,I.
J Biol Chem 280: 13568-13575.
 
YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.
2005
Tamar Kleinberger, PhD
Authors : Maoz T, Koren R, Ben-Ari I, Kleinberger T.
J Biol Chem ;280:41270-41277.
 
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation.
2004
Eyal Bengal, PhD
Authors : Penn BH, Bergstrom DA, Dilworth J, Bengal E, Tapscott SJ.
Genes Dev ;18:2348-2353.
 
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma.
2004
Dan Hershko, MD
Authors : Shapira M, Ben-Izhak O, Bishara B, Futerman B, Minkov I, Krausz MM, Pagano M, Hershko DD.
Cancer ;100:1615-1621.
 
Feeder layer- and serum-free culture of human embryonic stem cells.
2004
Joseph Itskovitz-Eldor, MD, DSc
Authors : Amit M, Shariki C, Margulets V, Itskovitz-Eldor J.
Biol Reprod ;70:837-845.
 
Hairy transcriptional repression targets and cofactor recruitment in Drosophila.
2004
Amir Orian, MD, PhD
Authors : Bianchi-Frias D, Orian A, Delrow J, Vazquez J, Rosales-Nieves AE, Parkhurst SM.
PLoS Biology ;2:e178.
 
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
2004
Israel Vlodavsky, PhD
Authors : Edovitsky E, Elkin M, Zcharia E, Peretz T, Vlodavsky I.
J Natl Cancer Inst ;96:1219-1230.
 
Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors.
2004
Adi Salzberg, DSc
Authors : Inbal A, Volk T, Salzberg A.
Dev Cell ;7:241-250.
 
Rpb4 and Rpb7: subunits of RNA polymerase II and beyond.
2004
Mordechai (Motti) Choder, PhD
Authors : Choder M.
Trends Biochem Sci;29:674-681.
 
Semaphorin-3F is an inhibitor of tumor angiogenesis.
2004
Gera Neufeld, PhD
Authors : Kessler O, Shraga-Heled N, Lange T, Gutmann-Raviv N, Sabo E, Baruch L, Machluf M, Neufeld G.
Cancer Res ;64:1008-1015.
 
The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene.
2004
Ami Aronheim, PhD
Authors : Heinrich R, Livne E, Ben-Izhak O, Aronheim A.
J Biol Chem ;279:5708-5715.
 
The Meis3 protein and retinoid signaling interact to pattern the Xenopus hindbrain.
2004
Dale Frank, PhD
Authors : Dibner C, Elias S, Ofir R, Souopgui J, Kolm PJ, Sive H, Pieler T, Frank D.
Dev Biol ;271:75-86.
 
The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis.
2004
Tamar Kleinberger, PhD
Authors : Koren R, Rainis L, Kleinberger T.
J Biol Chem ;279:48598-48606.
 
Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways.
2004
Dale Frank, PhD
Authors : Aamar E, Frank D.
Development;131:153-163.
 
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
2003
Amir Orian, MD, PhD
Authors : Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LWM, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM, Eisenman RN.
Genes Dev;17:1101-1114.
 
Human embryonic stem cells as an in vitro model for human vascular development and the induction of vascular differentiation.
2003
Joseph Itskovitz-Eldor, MD, DSc
Authors : Gerecht-Nir S, Ziskind A, Itskovitz-Eldor J.
Lab Invest ;83:1811-1820.
 
Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo.
2003
Gera Neufeld, PhD
Authors : Akiri G, Sabo E, Dafni H, Vadasz Z, Kartvelishvily Y, Gan N, Kessler O, Cohen T, Resnick M, Neeman M, Neufeld G.
Cancer Res ;63:1657-1666.
 
Multiple roles for u-turn/ventral veinless in the development of Drosophila PNS.
2003
Adi Salzberg, DSc
Authors : Inbal A, Levanon D, Salzberg A.
Development ;130:2467-2478.
 
Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.
2003
Mordechai (Motti) Choder, PhD
Authors : Farago M, Nahari T, Hammel C, Cole CN, Choder M.
Mol Biol Cell ;14:2744-2755.
 
The mitogen-activated protein kinase cascade promotes myoblast cell survival by stabilizing the cyclin-dependent kinase inhibitor, p21WAF1 protein.
2003
Eyal Bengal, PhD
Authors : Ostrovsky O, Bengal E.
J Biol Chem ;278:21221-21231.
 
Differential targeting of the stress MAPKs to the c-Jun dimerization protein 2.
2002
Ami Aronheim, PhD
Authors : Katz S, Aronheim A.
Biochem J ;368:939-945.
 
Induction of terminal differentiation by the c-Jun dimerization protein, JDP2, in C2 myoblasts and rhabdomyosarcoma cells.
2002
Ami Aronheim, PhD  |   Eyal Bengal, PhD
Authors : Ostrovsky O, Bengal E, Aronheim A.
J Biol Chem ;277:40043-40054.
 
The Neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis.
2002
Gera Neufeld, PhD
Authors : Neufeld G, Cohen T, Shraga N, Lange T, Kessler O, Herzog Y.
Trends Cardiovasc Med;12:13-19.
 
Tail vein assay of cancer metastasis.
2001
Israel Vlodavsky, PhD
Authors : Elkin M
Curr Protoc Cell Biol. 2001 Nov;Chapter 19:Unit 19.2.
 
Preparation of extracellular matrices produced by cultured corneal endothelial and PF-HR9 endodermal cells.
2001
Curr Protoc Cell Biol. 2001 May;Chapter 10:Unit 10.4.
 
Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.
2001
Tamar Kleinberger, PhD
Authors : Kornitzer D, Sharf R, Kleinberger T.
J Cell Biol ;154:331-344.
 
Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.
2001
Adi Salzberg, DSc
Authors : Inbal A, Halachmi N, Dibner C, Frank D, Salzberg A.
Development ;128:3405-3413.
 
Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.
2001
Dan Hershko, MD
Authors : Hershko D, Bornstein G, Ben-Izhak O, Carrano A, Pagano M, Krausz MM, Hershko A.
Cancer ;91:1745-1751.
 
XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos.
2001
Dale Frank, PhD
Authors : Dibner C, Elias S, Frank D.
Development ;128:3415-3426.
 
Embryonic stem cell lines derived from human blastocysts.
1998
Joseph Itskovitz-Eldor, MD, DSc
Authors : Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM.
Science ;282:1145-1147.
 
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The Nobel Prize in Chemistry 2004

Professors Avram Hershko and Aaron Ciechanover - winners of the 2004 Nobel Prize in Chemistry.
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