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Immunity and Host Defense

 
Antigen-Dependent Integration of Opposing Proximal TCR-Signaling Cascades Determines the Functional Fate of T Lymphocytes
2014
Shai Shen-Orr, PhD
Authors : Wolchinsky R, Hod-Marco M, Oved K, Shen-Orr SS, Bendall SC, Nolan GP, Reiter Y.
J Immunol. 2014 Mar 1;192(5):2109-19.
 
Identification of functionally important conserved trans-membrane residues of bacterial P(IB) -type ATPases
2013
Oded Lewinson, PhD
Authors : Zhitnitsky D, Lewinson O.
Mol Microbiol. 2013 Dec 19. doi: 10.1111/mmi.12495. [Epub ahead of print] PubMed PMID: 24350798.
 
Variability in the immune system: of vaccine responses and immune states
2013
Shai Shen-Orr, PhD
Authors : Shen-Orr SS, Furman D.
Curr Opin Immunol. 2013 Aug;25(4):542-7.
 
Computational deconvolution: extracting cell type-specific information from heterogeneous samples.
2013
Shai Shen-Orr, PhD
Authors : Shen-Orr SS, Gaujoux R.
Curr Opin Immunol. 2013 Oct;25(5):571-8.
 
Challenges and promise for the development of human immune monitoring.
2013
Shai Shen-Orr, PhD
Authors : Shen-Orr S.
Rambam Maimonides Med J. 2012 Oct 31;3(4):e0023.
 
Homeostatic regulation of aging and rejuvenation in the B lineage cells
2013
Doron Melamed, PhD
Authors : Melamed D.
Crit Rev Immunol. 2013;33(1):41-56.
 
Variability in the immune system: of vaccine responses and immune states
2013
Shai Shen-Orr, PhD
Authors : Shen-Orr S, Furman D.
Curr Opin Immunol. 2013 Aug 13. doi:pii: S0952-7915(13)00113-1.
 
A single intact ATPase site of the ABC transporter BtuCD drives 5% transport activity yet supports full in-vivo vitamin B12 utilization.
2013
Oded Lewinson, PhD
Authors : Tal N, Ovcharenko E, Lewinson O.
Proc Natl Acad Sci U S A. (March 19 Epub ahead of print)
 
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness.
2013
Shai Shen-Orr, PhD
Authors : Furman D, Jojic V, Kidd B, Shen-Orr S, Price J, Jarrell J, Tse T, Huang H, Lund P, Maecker HT, Utz PJ, Dekker CL, Koller D, Davis MM.
Molecular Systems Biology. 9, 659
 
The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications.
2013
Nathan Karin, PhD
Authors : Shachar, I., and N. Karin.
J Leukoc Biol 93:51-61.
 
Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins.
2013
Oded Lewinson, PhD
Authors : Vigonsky, Ovcharenko E, Lewinson O.
Proc Natl Acad Sci U S A. (March 19 Epub ahead of print)
 
Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis.
2012
Nathan Karin, PhD
Authors : Izhak, L., G. Wildbaum, S. Jung, A. Stein, Y. Shaked, and N. Karin.
PloS one 7:e28305
 
Dose-related effects of hyperoxia on the lung inflammatory response in septic rats
2012
Nitza Lahat, PhD
Authors : Waisman D, Brod V, Rahat MA, Amit-Cohen BC, Lahat N, Rimar D, Menn-Josephy H, David M, Lavon O, Cavari Y, Bitterman H.
Shock. 2012 Jan;37(1):95-102.
 
Robust and sensitive analysis of xMap bead arrays using SAxCyB.
2012
Shai Shen-Orr, PhD
Authors : Won JH, Goldberger O, Shen-Orr SS, David MM, Olshen RA.
Proc Natl Acad Sci U S A. 109, 2848-53.
 
The Entamoeba histolytica methylated LINE-binding protein EhMLBP provides protection against heat shock
2012
Serge Ankri, PhD
Authors : Katz S, Kushnir O, Tovy A, Siman Tov R, Ankri S.
Cell Microbiol. 2012 Jan;14(1):58-70
 
Hypoxia increases membranal and secreted HLA-DR in endothelial cells, rendering them T-cell activators.
2011
Nitza Lahat, PhD
Authors : Lahat N, Bitterman H, Weiss-Cerem L, Rahat MA.
Transpl Int. 2011 Oct;24(10):1018-26.
 
The Entamoeba histolytica methylated LINE-binding protein EhMLBP provides protection against heat shock.
2011
Serge Ankri, PhD
Authors : Katz S, Kushnir O, Tovy A, Siman Tov R, Ankri S.
Cell Microbiol. 2011 Sep 8. [Epub ahead of print]
 
Dose-Related Effects of Hyperoxia on the Lung Inflammatory Response in Septic Rats. Shoc
2011
Nitza Lahat, PhD
Authors : Waisman D, Brod V, Rahat MA, Amit-Cohen BC, Lahat N, Rimar D, Menn-Josephy H, David M, Lavon O, Cavari Y, Bitterman H.
2011 Sep 3. [Epub ahead of print]
 
Glucose starvation boosts Entamoeba histolytica virulence.
2011
Serge Ankri, PhD
Authors : Tovy A, Hertz R, Siman-Tov R, Syan S, Faust D, Guillen N, Ankri S.
PLoS Negl Trop Dis. 2011 Aug;5(8):e1247.
 
The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
2011
Eur J Immunol. 2011 Aug;41(8):2424-35.
 
phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
2011
Deborah Yablonski, PhD
Authors : Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D. Sequential
EMBO J. 2011 Jul 1;30(15):3160-72.
 
The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
2011
Orly Avni, PhD
Authors : Hod-Dvorai R, Jacob E, Boyko Y, Avni O.
Eur J Immunol. 2011 Jun 15. [Epub ahead of print]
 
MMP expression in leaking filtering blebs and tears after glaucoma filtering surgery.
2011
Nitza Lahat, PhD
Authors : Mathalone N, Marmor S, Rahat MA, Lahat N, Oron Y, Geyer O.
Graefes Arch Clin Exp Ophthalmol. 2011 Mar 31. [Epub ahead of print]
 
B cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.
2011
Doron Melamed, PhD
Authors : Keren Z, Naor S, Nussbaum S Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D.
Blood 117, 3104 - 3112.
 
Chronic B cell deficiency from birth prevents age-related alterations in the B lineage J.
2011
Doron Melamed, PhD
Authors : Keren Z, Averbuch D, Shahaf G, Zisman-Rozen S, Golan K, Itkin T, Lapidot T, Mehr R, Melamed D.
Immunol 187, 2140 - 2147.
 
Epigenetics in the unicellular parasite Entamoeba histolytica.
2010
Serge Ankri, PhD
Authors : Tovy A, Ankri S.
Future Microbiol. 2010 Dec;5:1875-84.
 
The MAPK/ERK and PI3K pathways additively coordinate the transcription of recombination-activating genes in B lineage cells
2010
Orly Avni, PhD
Authors : Novak R, Jacob E, Haimovich J, Avni O, Melamed D.
J Immunol. 2010 Sep 15;185(6):3239-47
 
A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis
2010
Nathan Karin, PhD
Authors : Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, Karin N.
J Immunol. 2010 Aug 15;185(4):2589-99.
 
Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17
2010
Nathan Karin, PhD
Authors : Wildbaum G, Zohar Y, Karin N.
Am J Pathol. 2010 Jun; 176(6):2764-75.
 
Circulating interleukin-10: association with higher mortality in systolic heart failure patients with elevated tumor necrosis factor-alpha
2010
Nitza Lahat, PhD
Authors : Amir O, Rogowski O, David M, Lahat N, Wolff R, Lewis BS.
Isr Med Assoc J. 2010 Mar;12(3):158-62.
 
In vitro tRNA Methylation Assay with the Entamoeba histolytica DNA and tRNA Methyltransferase Dnmt2 (Ehmeth) Enzyme
2010
Serge Ankri, PhD
Authors : Tovy A, Hofmann B, Helm M, Ankri S.
J Vis Exp. 2010 Oct 19;(44). pii: 2390. doi: 10.3791/2390.
 
Circulating interleukin-10: association with higher mortality in systolic heart failure patients with elevated tumor necrosis factor-alpha
2010
Nitza Lahat, PhD
Authors : Amir O, Rogowski O, David M, Lahat N, Wolff R, Lewis BS
Isr Med Assoc J. 2010 Mar;12(3):158-62
 
A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation.
2010
Oded Lewinson, PhD
Authors : Lewinson O, Lee AT, Locher KP, Rees DC.
Nat Struct Mol Biol. 17, 332-8.
 
Extracting Cell-Type-Specific Gene Expression Differences from Complex Tissues.
2010
Shai Shen-Orr, PhD
Authors : Shen-Orr SS*, Tibshirani R*, Khatri P, Bodian DL, Staedtler F, Perry NM, Hastie T, Sarwal MM, Davis MM*, Butte AJ*.
Nature Methods 7, 287-9.
 
The MAPK/ERK and PI(3)K Pathways Additively Coordinate the Transcription of Recombination-Activating Genes in B Lineage Cells.
2010
Doron Melamed, PhD
Authors : Novak R, Jacob E, Haimovich J, Avni O, Melamed D.
Immunol 185, 3239 - 3247.
 
Protein denitrosylation: enzymatic mechanisms and cellular functions
2009
Moran Benhar, PhD
Authors : Benhar, M., Forrester, M.T., Stamler, J.S.
Nat. Rev. Mol. Cell Biol. 10:721-32.
 
Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha
2009
Nathan Karin, PhD
Authors : Bergman R, Ramon M, Wildbaum G, Avitan-Hersh E, Mayer E, Shemer A, Karin N.
J Dermatol Sci. 2009 Oct 1. Epub
 
The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis
2009
Nitza Lahat, PhD
Authors : Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, Huszar M, White MR, Dinarello CA, Apte RN.
J Immunol. 2009 Oct 1;183(7):4705-14.
 
Insights into the mechanism of DNA recognition by the methylated LINE binding protein EhMLBP of Entamoeba histolytica
2009
Serge Ankri, PhD
Authors : Lavi T, Siman-Tov R, Ankri S.
Mol Biochem Parasitol. 2009 Aug;166(2):117-25. Epub 2009 Mar 20.
 
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2
2009
Nathan Karin, PhD
Authors : Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, Seagal J, Yefenof E, Ayalon-Soffer M, Karin N
J Immunol. 2009 Jul 1;183(1):732-9
 
Selective autoantibody production against CCL3‭ ‬is associated with human type 1‭ ‬diabetes mellitus and serves as a novel biomarker for its diagnosis
2009
Nathan Karin, PhD
Authors : Shehadeh N‭, ‬Pollack S‭, ‬Wildbaum G‭, ‬Zohar Y‭, ‬Shafat I‭, ‬Makhoul R‭, ‬Daod E‭,‬
J Immunol‭. ‬2009‭ ‬Jun 15‭;‬182‭(‬12‭):‬8104-9
 
The effect of 100% oxygen on intestinal preservation and recovery following ischemia-reperfusion injury in rats
2009
Nitza Lahat, PhD
Authors : Sukhotnik I, Brod V, Lurie M, Rahat MA, Shnizer S, Lahat N, Mogilner JG, Bitterman H.
Crit Care Med. 2009 Mar;37(3):1054-61.
 
Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor
2009
Orly Avni, PhD
Authors : Scheinman EJ, Avni O.
J Biol Chem. 2009 30;284(5):3037-48.
 
TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors
2008
Doron Melamed, PhD
Authors : Edry E, Azulay-Debby H, Melamed D.
Int Immunol. 2008 Dec;20(12):1575-85. Epub 2008 Oct 29.
 
EhMLBP is an essential constituent of the Entamoeba histolytica epigenetic machinery and a potential drug target
2008
Serge Ankri, PhD
Authors : Lavi T, Siman-Tov R, Ankri S.
Mol Microbiol. 2008 Jul;69(1):55-66. Epub 2008 May 12
 
Hypoxia enhances lysosomal TNF-α degradation in mouse peritoneal macrophages
2008
Nitza Lahat, PhD
Authors : Lahat, N., Rahat, M. A., Kinarty, A., Weiss-Cerem, L., Pinchevski, S., Bitterman, H.
Am J Physiol Cell Physiol 295, C2-12.
 
What do unicellular organisms teach us about DNA methylation?
2008
Serge Ankri, PhD
Authors : Harony H
Trends Parasitol. 2008 May;24(5):205-9. Epub 2008 Apr 9. PMID: 18403268 [PubMed - in process]
 
Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins
2008
Moran Benhar, PhD
Authors : Benhar, M., Forrester, M.T., Hess, D.T., Stamler, J.S.
Science 320:1050-4
 
Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica.
2008
Serge Ankri, PhD
Authors : Isakov E, Siman-Tov R, Weber C, Guillen N
Mol Biochem Parasitol. 2008 Mar;158(1):82-94.
 
Progress and prospects of gene inactivation in Entamoeba histolytica.
2008
Serge Ankri, PhD
Authors : Abed M
Exp Parasitol. 2008 Feb;118(2):151-5
 
Class switch recombination: a friend and a foe.
2007
Doron Melamed, PhD
Authors : Edry E.
Clin Immunol. 2007 Jun;123(3):244-51.
 
Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9
2007
Nitza Lahat, PhD
Authors : Marom, B., Rahat, M. A., Lahat, N., Weiss-Cerem, L., Kinarty, A., Bitterman, H.
J Leukoc Biol 81, 1466-1476.
 
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.
2007
Deborah Yablonski, PhD
Authors : Bogin Y, Ainey C, Beach D
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6638-43.
 
Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.
2007
Deborah Yablonski, PhD
Authors : Beach D, Gonen R, Bogin Y, Reischl IG
J Biol Chem. 2007 Feb 2;282(5):2937-46. Epub 2006 Dec 4.
B cell receptor editing in tolerance and autoimmunity.
2007
Doron Melamed, PhD
Authors : Azulay-Debby H.
Front Biosci. 2007 Jan 1;12:2136-47.
 
Genome-wide analysis of mRNA polysomal profiles with spotted DNA microarrays.
2007
Doron Melamed, PhD
Authors : Arava Y.
Methods Enzymol. 2007;431:177-201
 
Coadministration of plasmid DNA constructs encoding an encephalitogenic determinant and IL-10 elicits regulatory T cell-mediated protective immunity in the central nervous system.
2006
Nathan Karin, PhD
Authors : Schif-Zuck S, Wildbaum G, Karin N.
J Immunol. 2006 Dec 1;177(11):8241-7.
 
Sensing DNA methylation in the protozoan parasite Entamoeba histolytica.
2006
Serge Ankri, PhD
Authors : Lavi T, Isakov E, Harony H, Fisher O, Siman-Tov R.
Mol Microbiol. 2006 Dec;62(5):1373-86.
Modulation of matrix metalloproteinase-9 (MMP-9) secretion in B lymphopoiesis.
2006
Doron Melamed, PhD
Authors : Melamed D, Messika O, Glass-Marmor L, Miller A.
Int Immunol. 2006 Sep;18(9):1355-62.
 
A Pak- and Pix-dependent branch of the SDF-1alpha signalling pathway mediates T cell chemotaxis across restrictive barriers.
2006
Deborah Yablonski, PhD
Authors : Volinsky N, Gantman A, Yablonski D.
Biochem J. 2006 Jul 1;397(1):213-22. PMID: 16515536 [PubMed - in process]
DNA methylation and targeting of LINE retrotransposons in Entamoeba histolytica and Entamoeba invadens.
2006
Serge Ankri, PhD
Authors : Harony H, Bernes S, Siman-Tov R, Ankri S.
Mol Biochem Parasitol. 2006 May;147(1):55-63. Epub 2006 Feb 23. PMID: 16530279 [PubMed – in process]
Pleiotropic phenotype in Entamoeba histolytica overexpressing DNA methyltransferase (Ehmeth).
2006
Serge Ankri, PhD
Authors : Fisher O, Siman-Tov R, Ankri S.
Mol Biochem Parasitol. 2006 May;147(1):48-54. Epub 2006 Feb 9. PMID: 16497397 [PubMed – in process]
Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association
2006
Nitza Lahat, PhD
Authors : Rahat, M. A., Marom, B., Bitterman, H., Weiss-Cerem, L., Kinarty, A., Lahat, N.
J Leukoc Biol 79, 706-718.
 
Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation
2006
Serge Ankri, PhD
Authors : Moncada D, Keller K, Ankri S, Mirelman D, Chadee K.
Gastroenterology. 2006 Mar;130(3):721-30. PMID: 16530514 [PubMed – indexed for MEDLINE]
Beneficial autoimmunity participates in the regulation of rheumatoid arthritis.
2006
Nathan Karin, PhD
Authors : Zohar Y, Wildbaum G, Karin N.
Front Biosci. 2006 Jan 1;11:368-79. Review. PMID: 16146738 [PubMed - indexed for MEDLINE]
The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs.
2005
Doron Melamed, PhD
Authors : Lotan R, Bar-On VG, Harel-Sharvit L, Duek L, Melamed D, Choder M.
Genes Dev. 2005 Dec 15;19(24):3004-16. PMID: 16357218 [PubMed - indexed for MEDLINE]
Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity.
2005
Doron Melamed, PhD
Authors : Mark-Danieli M, Laham N, Kenan-Eichler M, Castiel A, Melamed D, Landau M, Bouvier NM, Evans MJ, Bacharach E.
J Virol. 2005 Jun;79(12):7756-67. PMID: 15919928 [PubMed - indexed for MEDLINE]
Molecular characterization of Entamoeba histolytica Rnase III and AGO2, two RNA interference hallmark proteins.
2005
Serge Ankri, PhD
Authors : Abed M, Ankri S.
Exp Parasitol. 2005 Jul;110(3):265-9. Epub 2005 Apr 7. PMID: 15955322 [PubMed – indexed for MEDLINE]
Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells.
2005
Nathan Karin, PhD
Authors : Schif-Zuck S, Westermann J, Netzer N, Zohar Y, Meiron M, Wildbaum G, Karin N.
Immunol. 2005 Apr 1;174(7):4307-15. PMID: 15778395 [PubMed - indexed for MEDLINE]
T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.
2005
Deborah Yablonski, PhD
Authors : Gonen R, Beach D, Ainey C, Yablonski D.
J Biol Chem. 2005 Mar 4;280(9):8364-70. Epub 2004 Dec 28. PMID: 15623534 [PubMed - indexed for MEDLINE]
Naive, effector, and memory T lymphocytes efficiently scan dendritic cells in vivo: contact frequency in T cell zones of secondary lymphoid organs does not depend on LFA-1 expression and facilitates
2005
Nathan Karin, PhD
Authors : Westermann J, Bode U, Sahle A, Speck U, Karin N, Bell EB, Kalies K, Gebert A.
J Immunol. 2005 Mar 1;174(5):2517-24. PMID: 15728457 [PubMed - indexed for MEDLINE]
Antigen receptor signaling competence and the determination of B cell fate in B-lymphopoiesis.
2005
Doron Melamed, PhD
Authors : Keren Z, Melamed D.
Histol Histopathol. 2005 Jan;20(1):187-96. Review. PMID: 15578437 [PubMed - indexed for MEDLINE]
CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing.
2005
Doron Melamed, PhD
Authors : Diamant E, Keren Z, Melamed D.
Blood ;105:3247-3254.
 
Entamoeba histolytica DNA methyltransferase (Ehmeth) is a nuclear matrix protein that binds EhMRS2, a DNA that includes a scaffold/matrix attachment region (S/MAR).
2005
Serge Ankri, PhD
Authors : Banerjee S, Fisher O, Lohia A, Ankri S.
Mol Biochem Parasitol. 2005 Jan;139(1):91-7. PMID: 15610823 [PubMed – indexed for MEDLINE]
Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression.
2005
Serge Ankri, PhD
Authors : Bernes S, Siman-Tov R, Ankri S.
FEBS Lett;579:6395-6402.
 
T cell receptor-induced activation of phospholipase C-γ1 depends on a sequence-independent function of the P-I region of SLP-76.
2005
Deborah Yablonski, PhD
Authors : Gonen R, Beach D, Ainey C, Yablonski D.
J Biol Chem ;280:8364-8370.
 
Characterization of cytosine methylated regions and 5-cytosine DNA methyltransferase (Ehmeth) in the protozoan parasite Entamoeba histolytica.
2004
Serge Ankri, PhD
Authors : Fisher O, Siman-Tov R, Ankri S.
Nucleic Acids Res ;1:287-297.
 
Modification of ligandindependent B cell receptor tonic signals activates receptor editing in immature B lymphocytes.
2004
Doron Melamed, PhD
Authors : Keren Z, Diamant E, Ostrovsky O, Bengal E, Melamed D.
J Biol Chem ;279:13418-13424.
 
A failsafe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway
2003
Doron Melamed, PhD
Authors : Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, Melamed D.
J Exp Med ;198:1609-1619.
 
Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity.
2003
Nathan Karin, PhD
Authors : Wildbaum G, Nahir MA, Karin N.
Immunity;19:679-688.
 
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.
2002
Orly Avni, PhD
Authors : Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A.
Nat Immunol ;3:643-651.
 
Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading.
2002
Nathan Karin, PhD
Authors : Wildbaum G, Netzer N, Karin N.
J Clin Invest ;110:701-710.
 
A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.
2001
Deborah Yablonski, PhD
Authors : Ku GM, Yablonski D, Manser E, Lim L, Weiss A.
EMBO Journal ;20:457-465.
 
Identification of a phospholipase C-γ1 (PLC- γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
2001
Deborah Yablonski, PhD
Authors : Yablonski D, Kadlecek T, Weiss A.
Mol Cell Biol ;21:4208-4218.
 
C-C chemokineencoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis.
2000
Nathan Karin, PhD
Authors : Youssef S, Maor G, Wildbaum G, Grabie N, Gour-Lavie A, Karin N.
J Clin Invest ;106:361-371.
 
Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo.
2000
Orly Avni, PhD
Authors : Agarwal S, Avni O, Rao A.
Immunity ;12:643-652.
 
T cell differentiation: a mechanistic view.
2000
Orly Avni, PhD
Authors : Avni O, Rao A.
Curr Opin Immunol; 12:654-659.
 
A systemic cytokine response defect stratifies older adults into distinct immune profiles.
1900
Shai Shen-Orr, PhD
Authors : Shen-Orr SS*, Furman D*, Kidd BA, Morgan A, Lovelace P, Rosenberg-Hasson Y, Maecker H, Mackey S, Dekker C, Butte AJ, Davis MM.
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