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The Ubiquitin System and Cellular Protein Turnover and Interactions

 
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
2014
Aaron Ciechanover, MD, DSc
Authors : Rossi M, Rotblat B, Ansell K, Amelio I, Caraglia M, Misso G, Bernassola F, Cavasotto CN, Knight RA, Ciechanover A, Melino G.
Cell Death Dis. 2014 May 1;5:e1203.
 
Nonenzymatic polyubiquitination of expressed proteins
2014
Aaron Ciechanover, MD, DSc
Authors : Hemantha HP, Bavikar SN, Herman-Bachinsky Y, Haj-Yahya N, Bondalapati S, Ciechanover A, Brik A.
J Am Chem Soc. 2014 Feb 12;136(6):2665-73.
 
Pulse-chase analysis to measure protein degradation
2014
Daniel Kornitzer, PhD
Authors : Simon E, Kornitzer D.
Methods Enzymol. 2014;536:65-75.
 
The complexity of recognition of ubiquitinated substrates by the 26S proteasome
2014
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A, Stanhill A.
Biochim Biophys Acta. 2014 Jan;1843(1):86-96.
 
α-Synuclein Ubiquitination and Novel Therapeutic Targets for Parkinson's Disease.
2013
Simone Engelender, MD, PhD
Authors : Rott R, Szargel R, Shani V, Bisharat S, Engelender S.
CNS Neurol Disord Drug Targets. 2013 Oct 28. [Epub ahead of print] PubMed PMID: 24168368.
 
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
2013
Aaron Ciechanover, MD, DSc
Authors : Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A.
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17726-31.
 
Modifying the Vicinity of the Isopeptide Bond to Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins: Organic Chemistry Applied to Synthetic Proteins
2013
Aaron Ciechanover, MD, DSc
Authors : Haj-Yahya N, Haj-Yahya M, Castaeda CA, Spasser L, Hemantha HP, Jbara M, Penner M, Ciechanover A, Fushman D, Brik A.
Angew Chem Int Ed Engl. 2013 Sep 4. doi: 10.1002/anie.201306118. [Epub ahead of print]
 
Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly
2013
Dan Hershko, MD
Authors : Eytan E, Sitry-Shevah D, Teichner A, Hershko A.
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10568-73.
 
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.
2013
Aaron Ciechanover, MD, DSc
Authors : Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A.
Proc Natl Acad Sci U S A. 2013 Sep 16. [Epub ahead of print] PubMed PMID: 24043770.
 
Phosphorylation of the cyclin CaPcl5 modulates both cyclin stability and specific recognition of the substrate
2013
Daniel Kornitzer, PhD
Authors : Simon E, Gildor T, Kornitzer D.
J Mol Biol. 2013 Sep 9;425(17):3151-65.
 
Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
2013
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Bioorg Med Chem. 2013 Jun 15;21(12):3400-10.
 
AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.
2013
Simone Engelender, MD, PhD
Authors : Haskin J, Szargel R, Shani V, Mekies LN, Rott R, Lim GG, Lim KL, Bandopadhyay R, Wolosker H, Engelender S.
Hum Mol Genet. 2013 May 15;22(10):2083-96.
 
The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
2013
Aaron Ciechanover, MD, DSc
Authors : Kravtsova-Ivantsiv Y, Sommer T, Ciechanover A.
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):192-8.
 
AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.
2013
Simone Engelender, MD, PhD
Authors : Haskin J, Szargel R, Shani V, Mekies LN, Rott R, Lim GG, Lim KL, Bandopadhyay R, Wolosker H, Engelender S.
Hum Mol Genet. 22, 2083-96.
 
Role of phosphorylation of Cdc20 in p31comet-stimulated disassembly of the mitotic checkpoint complex.
2012
Dan Hershko, MD
Authors : Miniowitz-Shemtov S, Eytan E, Ganoth D, Sitry-Shevah D, Dumin E, Hershko A.
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8056-60.
 
HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation
2012
Aaron Ciechanover, MD, DSc
Authors : Noy T, Suad O, Taglicht D, Ciechanover A.
Biochem Biophys Res Commun. 2012 Feb 10;418(2):408-13
 
Non-canonical ubiquitin-based signals for proteasomal degradation.
2012
Aaron Ciechanover, MD, DSc
Authors : Kravtsova-Ivantsiv Y, Ciechanover A.
J Cell Sci. 2012 Feb 1;125(Pt 3):539-48.
 
FAT10 is a proteasomal degradation signal which is itself regulated by ubiquitination.
2012
Aaron Ciechanover, MD, DSc
Authors : Buchsbaum S, Bercovich B, Ciechanover A.
Mol Biol Cell. 2012 Jan;23(1):225-32.
 
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
2012
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Biochim Biophys Acta. 2012 Jan;1824(1):3-13.
 
Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans
2012
Daniel Kornitzer, PhD
Authors : Sela N, Atir-Lande A, Kornitzer D.
Eukaryot Cell. 2012 Jan;11(1):42-52.
 
Role of a Candida albicans Nrm1/Whi5 homolog in cell cycle gene expression and DNA replication stress response.
2012
Daniel Kornitzer, PhD
Authors : Ofir A, Hofmann K, Weindling E, Gildor T, Baker K, Rogers PD, Kornitzer D.
Mol. Microbiology 84, 778-794.
 
The Size of the Proteasomal Substrate Determines whether its Degradation will be Mediated by Mono- or Polyubiquitylation.
2012
Aaron Ciechanover, MD, DSc
Authors : Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A.
Mol. Cell 48, 87-97.
 
Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans.
2011
Daniel Kornitzer, PhD
Authors : Sela N, Atir-Lande A, Kornitzer D.
Eukaryot Cell. 2011 Nov 11. [Epub ahead of print]
 
Stalled proteasomes are directly relieved by p97 recruitment.
2011
Ariel Stanhill, PhD
Authors : Isakov E, Stanhill A.
J Biol Chem. 2011 Sep 2;286(35):30274-83.
 
Stalled proteasomes are directly relieved by P97 recruitment.
2011
J Biol Chem. 2011 Sep 2;286(35):30274-83.
 
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.
2011
Cell Death Differ. 2011 Sep;18(9):1393-402.
 
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
2011
Aaron Ciechanover, MD, DSc
Authors : Zoabi M, Sadeh R, de Bie P, Ciechanover A.
Biochem Biophys Res Commun. 2011 May 13;408(3):393-8.
 
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
2011
13;408(3):393-8. Res Commun. 2011 Jul 8;410(3):705.
 
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
2011
Dan Hershko, MD
Authors : Moshe Y, Bar-On O, Ganoth D, Hershko A.
J Biol Chem. 2011 May 13;286(19):16647-57.
 
Regulation of the action of early mitotic inhibitor 1 on the Anaphase-Promoting Complex/Cyclosome by Cyclin-Dependent Kinases.
2011
Dan Hershko, MD
Authors : Moshe Y, Bar-On O, Ganoth D, Hershko A
J Biol Chem. 2011 Mar 16. [Epub ahead of print]
 
Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks.
2011
Aaron Ciechanover, MD, DSc
Authors : Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y.
Mol Cell. 2011 Mar 4;41(5):529-42.
 
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.
2011
Aaron Ciechanover, MD, DSc
Authors : de Bie P, Ciechanover A.
Cell Death Differ. 2011 Mar 4. [Epub ahead of print]
 
p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.
2011
Avram Hershko, MD, PhD
Authors : Teichner A, Eytan E, Sitry-Shevah D, Miniowitz-Shemtov S, Dumin E, Gromis J, Hershko A.
Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3187-92.
 
α-Synuclein fate is determined by USP9X-regulated monoubiquitination.
2011
Simone Engelender, MD, PhD
Authors : Rott R, Szargel R, Haskin Y, Bandopadhyay R, Lee, AJ, Shani V and Engelender S.
Proc. Natl. Acad. Sci. U.S.A. 108, 18666-71.
 
Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor.
2011
Aaron Ciechanover, MD, DSc
Authors : Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A.
Adv Exp Med Biol. 2011;691:95-106.
 
The Predator Becomes the Prey: Regulating the Ubiquitin System by Ubiquitylation and Degradation.
2011
Aaron Ciechanover, MD, DSc
Authors : Weissman AM, Shabek N, Ciechanover A.
Nature Rev. Mol. Cell. Biol.12, 605-620.
 
Ubiquitination and degradation of proteins.
2011
Aaron Ciechanover, MD, DSc
Authors : Kravtsova-Ivantsiv Y, Ciechanover A.
Methods Mol Biol. 2011;753:335-57.
 
Candida albicans cyclin Clb4 carries S-phase cyclin activity
2010
Daniel Kornitzer, PhD
Authors : Ofir A, Kornitzer D.
Eukaryot Cell. 2010 Sep;9(9):1311-9.
 
Regulation of the Polycomb protein RING1B ubiquitination by USP7.
2010
Aaron Ciechanover, MD, DSc
Authors : de Bie P, Zaaroor-Regev D, Ciechanover A.
Biochem Biophys Res Commun. 2010 Sep 24;400(3):389-95.
 
C. albicans cyclin Clb4 carries S-phase cyclin activity
2010
Daniel Kornitzer, PhD
Authors : Ofir A, Kornitzer D.
Eukaryot Cell. 2010 Jul 16. [Epub ahead of print]
 
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint.
2010
Avram Hershko, MD, PhD
Authors : Miniowitz-Shemtov S, Teichner A, Sitry-Shevah D, Hershko A.
Proc. Natl. Acad. Sci. USA 107, 5351-5356.
 
The Hul5 ubiquitin ligase promotes proteasomal processivity.
2010
Daniel Kornitzer, PhD
Authors : Aviram S and Kornitzer D.
Mol. Cell. Biol. 30, 985-994.
 
The ubiquitin ligase Hul5‭ ‬promotes proteasomal processivity
2009
Daniel Kornitzer, PhD
Authors : Aviram S‭, ‬Kornitzer D‭.
Mol Cell Biol‭. . [‬Epub ahead of print‭]
 
ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor
2009
Aaron Ciechanover, MD, DSc
Authors : Cohen S, Ciechanover A, Kravtsova-Ivantsiv Y, Lapid D, Lahav-Baratz S.
Biochem Biophys Res Commun. 2009 Nov 13;389(2):205-10
 
The 26S proteasome - from basic mechanisms to drug targeting
2009
Aaron Ciechanover, MD, DSc
Authors : Navon A, Ciechanover A.
J Biol Chem. 2009 Oct 7. [Epub ahead of print]
 
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation
2009
Aaron Ciechanover, MD, DSc
Authors : Shabek N, Herman-Bachinsky Y, Ciechanover A.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11907-12.
 
Fungal mechanisms for host iron acquisition
2009
Daniel Kornitzer, PhD
Authors : Kornitzer D‭.
Curr Opin Microbiol‭. 2009‭ Jun 18
 
Tracing the history of the ubiquitin proteolytic system‭: The pioneering article
2009
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A‭.
Biochem Biophys Res Commun‭. 2009‭ Jun 17‭.
 
Some lessons from my work on the biochemistry of the ubiquitin system
2009
Avram Hershko, MD, PhD
Authors : Hershko A‭.
J Biol Chem‭. ‬2009‭ ‬Apr 17‭;‬284‭(‬16‭):‬10291-5‭.
 
Synphilin-1A inhibits SIAH and modulates α-synuclein monoubiquitylation and inclusion formation.
2009
Simone Engelender, MD, PhD
Authors : Szargel R, Rott R, Eyal A, Haskin Y, Shani V and Engelender S.
J. Biol. Chem. 284, 1706-16.
 
Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation
2008
Daniel Kornitzer, PhD
Authors : Aviram S, Simon E, Gildor T, Glaser F, Kornitzer D.
Mol Cell Biol. 2008 Nov;28(22):6858-69. Epub 2008 Sep 15.
 
The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system
2008
Aaron Ciechanover, MD, DSc
Authors : Sadeh R, Breitschopf K, Bercovich B, Zoabi M, Kravtsova-Ivantsiv Y, Kornitzer D, Schwartz A, Ciechanover A.
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15690-5. Epub 2008 Oct 3
 
Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease
2008
Simone Engelender, MD, PhD
Authors : Engelender S.
Autophagy. 2008 May-Jun;4(3):372-4. Epub 2008 Jan 18. Review. PMID: 18216494
Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20
2008
Avram Hershko, MD, PhD
Authors : Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A.
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9181-5. Epub 2008 Jun 30
 
An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans
2008
Daniel Kornitzer, PhD
Authors : Weissman Z, Shemer R, Conibear E, Kornitzer D.
Mol Microbiol. 2008 Jul;69(1):201-17. Epub 2008 May 5.
 
Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans.
2008
Ariel Stanhill, PhD
Authors : Yun, C., Stanhill, A., Yang, Y., Zhang, Y., Haynes, C. M., Xu, C. F., Neubert, T. A., Mor, A., Philips, M. R., Ron, D.
Proc Natl Acad Sci U S A 105, 7094-7099.
 
Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.
2008
Simone Engelender, MD, PhD
Authors : Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E
J Biol Chem. 2008 Feb 8;283(6):3316-28.
 
An endocytic mechanism for hemoglobin-iron acquisition in Candida albicans.
2008
Daniel Kornitzer, PhD
Authors : Weissman Z, Shemer R, Conibear E, Kornitzer D.
Mol. Microbiol. 69, 201-217.
 
CXCL12 (SDF-1{alpha}) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
2008
Nathan Karin, PhD
Authors : Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N.
J Exp Med 205, 2643-2655.
 
Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.
2008
Simone Engelender, MD, PhD
Authors : Szargel R, Rott R
Cell Mol Life Sci. 2008 Jan;65(1):80-8.
 
Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004.
2007
Ann N Y Acad Sci. 2007 Nov;1116:1-28.
 
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.
2007
Avram Hershko, MD, PhD
Authors : Braunstein I, Miniowitz S, Moshe Y
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4870-5.
 
The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.
2006
Aaron Ciechanover, MD, DSc
Authors : Ben-Saadon R,Zaaroor D, Ziv T, Ciechanover A.
Mol Cell. 2006 Dec 8;24(5):701-11.
 
An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity
2006
Ariel Stanhill, PhD
Authors : Stanhill, A., Haynes, C. M., Zhang, Y., Min, G., Steele, M. C., Kalinina, J., Martinez, E., Pickart, C. M., Kong, X.-P., Ron, D.
Mol Cell 23, 875-885.
 
Synphilin Isoforms and the Search for a Cellular Model of Lewy Body Formation in Parkinson's Disease.
2006
Simone Engelender, MD, PhD
Authors : Eyal A, Engelender S.
Cell Cycle. 2006 Sep 15;5(18)
 
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
2006
Avram Hershko, MD, PhD
Authors : Bornstein G, Ganoth D, Hershko A.
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20
 
Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis.
2006
Aaron Ciechanover, MD, DSc
Authors : Cohen S, Lahav-Baratz S, Ciechanover A.
Biochem Biophys Res Commun. 2006 Jun 23;345(1):7-13. Epub 2006 Apr 24. PMID: 16678126 [PubMed - indexed for MEDLINE]
 
Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.
2006
Simone Engelender, MD, PhD
Authors : Franck T, Krueger R, Woitalla D, Muller T, Engelender S, Riess O.
J Neural Transm. 2006 Jun 6; [Epub ahead of print]
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.
2006
Aaron Ciechanover, MD, DSc
Authors : Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI.
Circ Res. 2006 May 26;98(10):1314-22. Epub 2006 Apr 13.
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
2006
Simone Engelender, MD, PhD
Authors : Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S.
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5917-22. Epub 2006 Apr 4. PMID: 16595633 [PubMed - indexed for MEDLINE]
The ubiquitin system and morphogenesis of fungal pathogens.
2006
Daniel Kornitzer, PhD
Authors : Kornitzer D.
Isr Med Assoc J. 2006 Apr;8(4):243-5. Review. PMID: 16671358 [PubMed - indexed for MEDLINE]
Ha-rasval12 induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-rasval12-transformed cells
2006
Ariel Stanhill, PhD
Authors : Stanhill, A., Levin, V., Hendel, A., Shachar, I., Kazanov, D., Arber, N., Kaminski, N., Engelberg, D.
Oncogene 25, 1485-1495.
 
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.
2006
Avram Hershko, MD, PhD
Authors : Eytan E, Moshe Y, Braunstein I, Hershko A.
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2081-6. Epub 2006 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242. PMID: 16455800 [PubMed - indexed for MEDLINE]
The ubiquitin proteolytic system: from an idea to the patient bed.
2006
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Proc Am Thorac Soc. 2006;3(1):21-31.
 
Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.
2005
Simone Engelender, MD, PhD
Authors : Avraham E, Szargel R, Eyal A, Rott R, Engelender S.
J Biol Chem. 2005 Dec 30;280(52):42877-86. Epub 2005 Sep 20.
The ubiquitin proteolytic system. From a vague idea, through basic mechanisms, and onto human diseases and drug targeting.
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Neurology. 2005 Dec 16; [Epub ahead of print] No abstract available. PMID: 16361379 [PubMed - as supplied by publisher]
Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition.
2005
Simone Engelender, MD, PhD
Authors : Bandopadhyay R, Kingsbury AE, Muqit MM, Harvey K, Reid AR, Kilford L, Engelender S, Schlossmacher MG, Wood NW, Latchman DS, Harvey RJ, Lees AJ.
Neurobiol Dis. 2005 Nov;20(2):401-11. PMID: 15894486 [PubMed - indexed for MEDLINE]
Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture).
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Angew Chem Int Ed Engl. 2005 Sep 19;44(37):5944-67.
E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1.
2005
Aaron Ciechanover, MD, DSc
Authors : Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL.
Oncogene. 2005 Sep 22;24(42):6376-84.
Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD.
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Cell Death Differ. 2005 Sep;12(9):1167-77. No abstract available.
Early work on the ubiquitin proteasome system, an interview with Avram Hershko. Interview by CDD.
2005
Avram Hershko, MD, PhD
Authors : Hershko A.
Cell Death Differ. 2005 Sep;12(9):1158-61. No abstract available.
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Cell Death Differ. 2005 Sep;12(9):1178-90. Review.
The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.
2005
Avram Hershko, MD, PhD
Authors : Hershko A.
Cell Death Differ. 2005 Sep;12(9):1191-7. Review. PMID: 16094395 [PubMed - indexed for MEDLINE]
The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture).
2005
Avram Hershko, MD, PhD
Authors : Hershko A.
Angew Chem Int Ed Engl. 2005 Sep 19;44(37):5932-43.
 
Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation.
2005
Aaron Ciechanover, MD, DSc
Authors : Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL.
J Biol Chem. 2005 Jul 15;280(28):26448-56. Epub 2005 May 11. PMID: 15888449 [PubMed - indexed for MEDLINE]
Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation.
2005
Aaron Ciechanover, MD, DSc
Authors : Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S.
J Biol Chem. 2005 Jul 8;280(27):25802-10. Epub 2005 Apr 18. PMID: 15837787 [PubMed - indexed for MEDLINE]
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
2005
Simone Engelender, MD, PhD
Authors : Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM.
J Neurosci. 2005 Feb 23;25(8):2002-9.
Coevolution of cyclin Pcl5 and its substrate Gcn4.
2005
Daniel Kornitzer, PhD
Authors : Gildor T, Shemer R, Atir-Lande A, Kornitzer D.
Eukaryot Cell. 2005 Feb;4(2):310-8. PMID: 15701793
A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization.
2005
Daniel Kornitzer, PhD
Authors : Weissman Z, Kornitzer D.
Mol Microbiol;53:1209-1220.
 
Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1.
2005
Avram Hershko, MD, PhD
Authors : Hershko A.
Methods Enzymol. 2005;398:170-5.
Glycogen synthase kinase 3b modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: IMPLICATIONS FOR PROTEASOMAL FUNCTION AND LEWY BODY FORMATION.
2005
Simone Engelender, MD, PhD
Authors : Avraham E, Szargel R, Eyal A, Rott R, Engelender S.
J Biol Chem;280:42877-42886.
 
N-terminal ubiquitination.
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Methods Mol Biol. 2005;301:255-70.
Proteolysis: from the lysosome to ubiquitin and the proteasome.
2005
Aaron Ciechanover, MD, DSc
Authors : Ciechanover A.
Nat Rev Mol Cell Biol ;6:79-87.
 
Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesis.
2005
Daniel Kornitzer, PhD
Authors : Atir-Lande A, Gildor T, Kornitzer D.
Mol Biol Cell ;16:2772-2785.
 
The ubiquitin-proteasome system--micro target for macro intervention?
2005
Aaron Ciechanover, MD, DSc
Authors : Herrmann J, Ciechanover A, Lerman LO, Lerman A.
Int J Cardiovasc Intervent. 2005;7(1):5-13. Review. PMID: 16019609 [PubMed - indexed for MEDLINE]
Dual effects of IkappaB kinase betamediated phosphorylation on p105 Fate: SCFβ-TrCP-dependent degradation and SCFβ-TrCP-independent processing.
2004
Aaron Ciechanover, MD, DSc
Authors : Cohen S, Achbert-Weiner H, Ciechanover A.
Mol Cell Biol ;24:475-486.
 
The tumor suppressor protein p16INK4a and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquit
2004
Aaron Ciechanover, MD, DSc
Authors : Ben-Saadon R, Fajerman I, Ziv T, Hellman U, Schwartz AL, Ciechanover A.
J Biol Chem ;279:41414-41421.
 
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
2004
Simone Engelender, MD, PhD
Authors : Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Rott R, Engelender S.
Proc Natl Acad Sci USA ;101:5500-5505.
 
Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by a-synuclein.
2002
Simone Engelender, MD, PhD
Authors : Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S.
J Biol Chem ;277:23927-23933.
 
The cellcycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27.
2001
Avram Hershko, MD, PhD
Authors : Ganoth D, Bornstein G, To KK, Larsen B, Tyers M, Pagano M, Hershko A.
Nat Cell Biol;3:321-324.
 
SKP2 is required for ubiquitinmediated degradation of the CDK inhibitor p27.
1999
Avram Hershko, MD, PhD
Authors : Carrano AC, Eytan E, Hershko A, Pagano M.
Nat Cell Biol ;1:193-199.
 
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
1995
Avram Hershko, MD, PhD
Authors : Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A.
Mol Biol Cell ;6:185-197.
 
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
1992
Nathan Karin, PhD
Authors : Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N.
Nature 356, 63-66.
 
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The Nobel Prize in Chemistry 2004

Professors Avram Hershko and Aaron Ciechanover - winners of the 2004 Nobel Prize in Chemistry.
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