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Vascular smooth muscle cells (VSMCs) play key roles in development, function and homeostasis of the vasculature.
Gene regulation is fundamental to every aspect of organismal biology. The onset of tissue-specific gene expression in higher organisms depends on the function of genomic elements called distal enhancers.
Cell functionality relies on the communication between its pathways, processes and machineries. This becomes even more critical for proper responses to stresses.
Huntington’s disease (HD) is a progressive and fatal neurological disorder associated with severe motor and psychiatric symptoms.
Amyotrophic lateral sclerosis, ALS, is a neurodegenerative disease with no cure or treatment, leading to gradual paralysis and death within a few years of onset.
Our goal is providing a novel cellular mechanism for a long-standing system’s level question of basal ganglia-mediated action initiation, and defining its role in the pathogenesis of Parkinson's disease (PD).